Alexander W Schuttelkopf
Overview
Explore the profile of Alexander W Schuttelkopf including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
2467
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Recent Articles
1.
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence
Pathak S, Alonso J, Schimpl M, Rafie K, Blair D, Borodkin V, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(4):564.
PMID: 36869195
No abstract available.
2.
Francis S, Croft D, Schuttelkopf A, Parry C, Pugliese A, Cameron K, et al.
Bioorg Med Chem Lett
. 2019 Feb;
29(8):1023-1029.
PMID: 30773430
Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role...
3.
Birch J, Strathdee K, Gilmour L, Vallatos A, McDonald L, Kouzeli A, et al.
Cancer Res
. 2018 Oct;
78(22):6509-6522.
PMID: 30279244
Glioblastoma (GBM) is an aggressive and incurable primary brain tumor that causes severe neurologic, cognitive, and psychologic symptoms. Symptoms are caused and exacerbated by the infiltrative properties of GBM cells,...
4.
Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, et al.
Cancer Res
. 2018 Feb;
78(8):2096-2114.
PMID: 29382705
The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The...
5.
Unbekandt M, Croft D, Crighton D, Mezna M, McArthur D, McConnell P, et al.
Cell Commun Signal
. 2014 Oct;
12:54.
PMID: 25288205
Background: The myotonic dystrophy kinase-related CDC42-binding kinases MRCKα and MRCKβ regulate actin-myosin contractility and have been implicated in cancer metastasis. Along with the related ROCK1 and ROCK2 kinases, the MRCK...
6.
Schuttelkopf A, Andersen O, Rao F, Allwood M, Rush C, Eggleston I, et al.
ACS Med Chem Lett
. 2014 Jun;
2(6):428-32.
PMID: 24900325
Chitinases of the GH18 family play important roles in a variety of pathogenic organisms and have also been shown to be involved in human asthma progression, making these enzymes potential...
7.
Rao F, Schuttelkopf A, Dorfmueller H, Ferenbach A, Navratilova I, van Aalten D
Open Biol
. 2013 Oct;
3(10):130021.
PMID: 24088714
The dynamic modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc) is an essential posttranslational modification present in higher eukaryotes. Removal of O-GlcNAc is catalysed by O-GlcNAcase, a multi-domain enzyme that has...
8.
Striebeck A, Robinson D, Schuttelkopf A, van Aalten D
Open Biol
. 2013 Sep;
3(9):130022.
PMID: 24026536
The fungal cell possesses an essential carbohydrate cell wall. The outer layer, mannan, is formed by mannoproteins carrying highly mannosylated O- and N-linked glycans. Yeast mannan biosynthesis is initiated by...
9.
Schimpl M, Zheng X, Borodkin V, Blair D, Ferenbach A, Schuttelkopf A, et al.
Nat Chem Biol
. 2012 Oct;
8(12):969-74.
PMID: 23103942
Protein O-GlcNAcylation is an essential post-translational modification on hundreds of intracellular proteins in metazoa, catalyzed by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) using unknown mechanisms of transfer and substrate recognition. Through...
10.
Lamb D, Schuttelkopf A, van Aalten D, Brighty D
PLoS Pathog
. 2011 Feb;
7(2):e1001268.
PMID: 21304939
Refolding of viral class-1 membrane fusion proteins from a native state to a trimer-of-hairpins structure promotes entry of viruses into cells. Here we present the structure of the bovine leukaemia...