Adel Chergui
Overview
Explore the profile of Adel Chergui including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
146
Followers
0
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Recent Articles
1.
Chergui A, Reagan J
Cancers (Basel)
. 2023 Aug;
15(16).
PMID: 37627165
Immunotherapy as a cancer treatment modality has undergone recent widespread proliferation across all cancer types, especially amongst patients with solid tumors. However, the longest tenured immunotherapy approach to cancer is...
2.
Hadfield M, Mistry H, Pelcovits A, Bansal R, Andrea S, Chergui A, et al.
Am J Clin Oncol
. 2023 Mar;
46(4):183-184.
PMID: 36959209
No abstract available.
3.
Friedman A, Chergui A, Leiderman E
Cureus
. 2020 Nov;
12(10):e10749.
PMID: 33150101
Abdominal paracentesis is a commonly performed diagnostic and therapeutic procedure with a low complication rate. Previously described complications include injury to the abdominal wall, small bowel perforation, and abdominal hemorrhage....
4.
Sukrithan V, Barbaro A, Chergui A, Ko B, Lin J, Cheng H, et al.
Am J Clin Oncol
. 2019 Nov;
43(1):64-68.
PMID: 31764022
Objectives: Bevacizumab with chemotherapy improved overall survival (OS) in the E4599 trial in metastatic nonsquamous non-small cell lung cancer (NS-NSCLC). A meta-analysis demonstrated an OS benefit with bevacizumab only in...
5.
Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson E, et al.
SLAS Discov
. 2017 Jul;
22(9):1093-1105.
PMID: 28697309
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in reversing inhibition of topoisomerase...
6.
Marchand C, Huang S, Dexheimer T, Lea W, Mott B, Chergui A, et al.
Mol Cancer Ther
. 2014 Jul;
13(8):2116-26.
PMID: 25024006
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully...
7.
Patel M, Bhatt A, Steffen J, Chergui A, Murai J, Pommier Y, et al.
J Med Chem
. 2014 Jun;
57(13):5579-601.
PMID: 24922587
Novel substituted 2,3-dihydrobenzofuran-7-carboxamide (DHBF-7-carboxamide) and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide (DHBF-3-one-7-carboxamide) derivatives were synthesized and evaluated as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). A structure-based design strategy resulted in lead compound 3 (DHBF-7-carboxamide; IC50 = 9.45...
8.
Murai J, Marchand C, Shahane S, Sun H, Huang R, Zhang Y, et al.
DNA Repair (Amst)
. 2014 May;
21:177-82.
PMID: 24794403
Anti-cancer topoisomerase I (Top1) inhibitors (camptothecin and its derivatives irinotecan and topotecan, and indenoisoquinolines) induce lethal DNA lesions by stabilizing Top1-DNA cleavage complex (Top1cc). These lesions are repaired by parallel...
9.
Beck D, Agama K, Marchand C, Chergui A, Pommier Y, Cushman M
J Med Chem
. 2014 Feb;
57(4):1495-512.
PMID: 24517248
Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the indenoisoquinoline system in search of structurally novel and potent Top1 inhibitors. The syntheses and biological...
10.
Conda-Sheridan M, Reddy P, Morrell A, Cobb B, Marchand C, Agama K, et al.
J Med Chem
. 2012 Dec;
56(1):182-200.
PMID: 23259865
Tyrosyl-DNA phosphodiesterase I (Tdp1) plays a key role in the repair of damaged DNA resulting from the topoisomerase I (Top1) inhibitor camptothecin and a variety of other DNA-damaging anticancer agents....