Andrew G Stephen
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Explore the profile of Andrew G Stephen including associated specialties, affiliations and a list of published articles.
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86
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2218
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Recent Articles
1.
Maciag A, Stice J, Wang B, Sharma A, Chan A, Lin K, et al.
Cancer Discov
. 2024 Dec;
15(3):578-594.
PMID: 39642212
Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct...
2.
Kwon J, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484452
To dissect variant-function relationships in the KRAS oncoprotein, we performed deep mutational scanning (DMS) screens for both wild-type and KRAS mutant alleles. We defined the spectrum of oncogenic potential for...
3.
Shree S, McLean M, Stephen A, Sligar S
Biochemistry
. 2024 Oct;
63(21):2740-2749.
PMID: 39382513
KRas4b is a small plasma membrane-bound G-protein that regulates signal transduction pathways. The interaction of KRas4b with the plasma membrane is governed by both its basic C-terminus, which is farnesylated...
4.
Stephen A
Trends Biochem Sci
. 2024 Oct;
49(11):933-935.
PMID: 39358051
A recent report by Yun et al. describes the detection of RAS dimers using intact mass spectrometry and investigates the role that membrane lipids, nucleotide state, and binding partners have...
5.
Mahran R, Kapp J, Valtonen S, Champagne A, Ning J, Gillette W, et al.
ACS Chem Biol
. 2024 Sep;
19(10):2152-2164.
PMID: 39283696
Mutated KRAS proteins are frequently expressed in some of the most lethal human cancers and thus have been a target of intensive drug discovery efforts for decades. Lately, KRAS(G12C) switch-II...
6.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins M, et al.
Cell
. 2024 Sep;
187(22):6379-6392.e17.
PMID: 39255801
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) that comprise cellular switch...
7.
DIppolito R, Scheidemantle G, Rabara D, Abreu Blanco M, Ramakrishnan N, Widmeyer S, et al.
Methods Mol Biol
. 2024 Jul;
2823:291-310.
PMID: 39052227
We present a novel method to determine engagement and specificity of KRAS4B-targeting compounds in vitro. By employing top-down mass spectrometry (MS), which analyzes intact and modified protein molecules (proteoforms), we...
8.
Shrestha R, Carpenter T, Van Q, Agamasu C, Tonelli M, Aydin F, et al.
Commun Biol
. 2024 Apr;
7(1):445.
PMID: 38605143
No abstract available.
9.
Larsen E, Abreu-Blanco M, Rabara D, Stephen A
Methods Mol Biol
. 2024 Apr;
2797:159-175.
PMID: 38570459
Homogenous time-resolved FRET (HTRF) assays have become one of the most popular tools for pharmaceutical drug screening efforts over the last two decades. Large Stokes shifts and long fluorescent lifetimes...
10.
Alexander P, Stephen A
Methods Mol Biol
. 2024 Apr;
2797:103-114.
PMID: 38570455
Surface plasmon resonance (SPR) is an optical effect at an electron-rich surface that enables affinity measurements of biomolecules in real time. It is label free and versatile, not limited to...