Adam H Metherel
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Explore the profile of Adam H Metherel including associated specialties, affiliations and a list of published articles.
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66
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631
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Recent Articles
1.
Valenzuela R, Metherel A, Cisbani G, Smith M, Chouinard-Watkins R, Klievik B, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2025 Jan;
1870(2):159594.
PMID: 39798684
The synthesis of n-3 and n-6 polyunsaturated acids (PUFAs) is associated with physiological functions in mammals, being catalyzed by Δ-5D and Δ-6D desaturases and elongases Elovl-2 and Elovl-5. In this...
2.
Chon J, Semnani-Azad Z, Lai K, Connelly P, Retnakaran R, Harris S, et al.
J Clin Endocrinol Metab
. 2024 Jun;
PMID: 38943663
Objectives: Although pre-clinical studies have shown a beneficial impact of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on adipose (AT) inflammation, the current literature from human studies is limited. Therefore, we...
3.
Rotarescu R, Mathur M, Bejoy A, Anderson G, Metherel A
J Nutr Biochem
. 2024 Jun;
131:109689.
PMID: 38876393
Females have higher docosahexaenoic acid (DHA) levels than males, proposed to be a result of higher DHA synthesis rates from α-linolenic acid (ALA). However, DHA synthesis rates are reported to...
4.
Rezaei K, Bejoy A, Rotarescu R, Klievik B, Metherel A
Prostaglandins Leukot Essent Fatty Acids
. 2024 May;
201:102621.
PMID: 38763083
Docosahexaenoic acid (DHA, 22:6n-3) must be consumed from the diet or synthesized from polyunsaturated fatty acid (PUFA) precursors, such as α-linolenic acid (ALA, 18:3n-3). Elongase 2 (encoded by Elovl2 gene)...
5.
Metherel A, Valenzuela R, Klievik B, Cisbani G, Rotarescu R, Gonzalez-Soto M, et al.
J Lipid Res
. 2024 Apr;
65(6):100548.
PMID: 38649096
DHA is abundant in the brain where it regulates cell survival, neurogenesis, and neuroinflammation. DHA can be obtained from the diet or synthesized from alpha-linolenic acid (ALA; 18:3n-3) via a...
6.
Cisbani G, Chouinard-Watkins R, Smith M, Malekanian A, Valenzuela R, Metherel A, et al.
Lipids
. 2023 Nov;
58(6):257-270.
PMID: 37997471
Consumption of a Western diet (WD) is known to increase the risk of obesity. Short or medium chain fatty acids influence energy metabolism, and triacetin, a synthetic short chain triacylglyceride,...
7.
Metherel A, Klievik B, Cisbani G, Smith M, Cumberford G, Bazinet R
Biochim Biophys Acta Mol Cell Biol Lipids
. 2023 Nov;
1869(1):159422.
PMID: 37977491
Ahiflower® oil is high in α-linolenic and stearidonic acids, however, tissue/blood docosahexaenoic acid (DHA, 22:6n-3) turnover from dietary Ahiflower oil has not been investigated. In this study, we use compound-specific...
8.
Chen D, Metherel A, Rezaei K, Parzanini C, Chen C, Ramsden C, et al.
J Lipid Res
. 2023 Aug;
64(9):100424.
PMID: 37572791
Natural variations in the C:C ratio (carbon-13 isotopic abundance [δC]) of the food supply have been used to determine the dietary origin and metabolism of fatty acids, especially in the...
9.
Valenzuela R, Metherel A, Cisbani G, Smith M, Chouinard-Watkins R, Klievik B, et al.
Biofactors
. 2023 Jul;
50(1):89-100.
PMID: 37470206
The synthesis rates of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in rodents and humans are not agreed upon and depend on substrate availability independently of the capacity for synthesis....
10.
Klievik B, Metherel A, Cisbani G, Valenzuela R, Bazinet R
J Lipid Res
. 2023 Mar;
64(5):100357.
PMID: 36948271
The brain is rich in DHA, which plays important roles in regulating neuronal function. Recently, using compound-specific isotope analysis that takes advantage of natural differences in carbon-13 content (C/C ratio...