Brian D Bennett
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Explore the profile of Brian D Bennett including associated specialties, affiliations and a list of published articles.
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33
Citations
896
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Recent Articles
1.
Serdar L, Egol J, Lackford B, Bennett B, Hu G, Silver D
PLoS Biol
. 2025 Feb;
23(2):e3003031.
PMID: 39913536
RNA abundance is controlled by rates of synthesis and degradation. Although mis-regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes to cortical development is largely unknown. Here,...
2.
Carswell G, Chamberlin J, Bennett B, Bushel P, Chorley B
Front Oncol
. 2024 May;
14:1389634.
PMID: 38764585
Background: Mechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations...
3.
Kinyamu H, Bennett B, Ward J, Archer T
Cancer Res Commun
. 2024 Apr;
4(4):1082-1099.
PMID: 38625038
Significance: Our study provides a strong basis for understanding the mechanisms by which proteasome inhibitors exert anticancer effects. We find open chromatin regions that change during proteasome inhibition, are typically...
4.
Hoang T, Lee Y, McCartney D, Kersten E, Page C, Hulls P, et al.
EBioMedicine
. 2024 Jan;
100:104956.
PMID: 38199042
Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero...
5.
Kinyamu H, Bennett B, Ward J, Archer T
bioRxiv
. 2023 Oct;
PMID: 37904968
Highlights: Proteasome inhibition uncovers Differential Open Chromatin Regions (DOCRs) in breast cancer cells. Proteasome inhibitor sensitive promoters exhibit a distinctive chromatin architecture with discrete transcription initiation patterns.Proteasome inhibition reprograms accessibility...
6.
Cho H, Wang X, Campbell M, Panduri V, Coviello S, Caballero M, et al.
Sci Rep
. 2023 Jul;
13(1):12262.
PMID: 37507442
Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease of prematurity with limited treatment options. To uncover biomarkers of BPD risk, this study investigated epigenetic and transcriptomic signatures of prematurity...
7.
Bisogno L, Yang J, Bennett B, Ward J, Mackey L, Annab L, et al.
Sci Adv
. 2020 Nov;
6(47).
PMID: 33219026
Induced pluripotent stem cells (iPSCs) can be derived from differentiated cells, enabling the generation of personalized disease models by differentiating patient-derived iPSCs into disease-relevant cell lines. While genetic variability between...
8.
Martos S, Campbell M, Lozoya O, Wang X, Bennett B, Thompson I, et al.
Cell Rep Med
. 2020 Nov;
1(4).
PMID: 33163982
Tobacco smoke exposure contributes to the global burden of communicable and chronic diseases. To identify immune cells affected by smoking, we use single-cell RNA sequencing on peripheral blood from smokers...
9.
Hoang T, Sikdar S, Xu C, Lee M, Cardwell J, Forno E, et al.
Eur Respir J
. 2020 May;
56(3).
PMID: 32381493
Epigenome-wide studies of methylation in children support a role for epigenetic mechanisms in asthma; however, studies in adults are rare and few have examined non-atopic asthma. We conducted the largest...
10.
Takaku M, Grimm S, De Kumar B, Bennett B, Wade P
Nucleic Acids Res
. 2020 Apr;
48(9):4756-4768.
PMID: 32232341
Estrogen receptors (ER) are activated by the steroid hormone 17β-estradiol. Estrogen receptor alpha (ER-α) forms a regulatory network in mammary epithelial cells and in breast cancer with the transcription factors...