Ad P Ijzerman
Overview
Explore the profile of Ad P Ijzerman including associated specialties, affiliations and a list of published articles.
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50
Citations
720
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Recent Articles
1.
Dudley M, Peet N, Demeter D, Weintraub H, Ijzerman A, Nordvall G, et al.
Drug Dev Res
. 2024 Jan;
28(3):237-243.
PMID: 38239889
This symposium provided a forum for presentations by the relevant groups on ligand design and ligand binding on the adenosine A, receptor. Agreement appears to exist that the "N-C" model...
2.
Jacobson K, Ijzerman A, Linden J
Drug Dev Res
. 2024 Jan;
47(1):45-53.
PMID: 38239816
The structure-activity relationships (SAR) of alkylxanthine derivatives as antagonists at the recombinant human adenosine receptors were explored in order to identify selective antagonists of A receptors. The effects of lengthening...
3.
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S145-S222.
PMID: 38123150
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
4.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, et al.
Nat Rev Drug Discov
. 2020 Apr;
19(7):429-430.
PMID: 32265506
No abstract available.
5.
Qile M, Ji Y, Golden T, Houtman M, Romunde F, Fransen D, et al.
Mol Pharmacol
. 2020 Apr;
97(6):355-364.
PMID: 32241959
Voltage-gated potassium 11.1 (K11.1) channels play a critical role in repolarization of cardiomyocytes during the cardiac action potential (AP). Drug-mediated K11.1 blockade results in AP prolongation, which poses an increased...
6.
Qile M, Beekman H, Sprenkeler D, Houtman M, van Ham W, Stary-Weinzinger A, et al.
Br J Pharmacol
. 2019 Jul;
176(19):3871-3885.
PMID: 31339551
Background And Purpose: K 11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of...
7.
van der Putten C, Veth J, Sukurova L, Zuiderwijk-Sick E, Simonetti E, Koenen H, et al.
J Immunol
. 2019 Feb;
202(8):2421-2430.
PMID: 30804043
TLR-induced signaling potently activates cells of the innate immune system and is subject to regulation at different levels. Inflammatory conditions are associated with increased levels of extracellular adenosine, which can...
8.
Yang X, Dong G, Michiels T, Lenselink E, Heitman L, Louvel J, et al.
Purinergic Signal
. 2016 Dec;
13(2):191-201.
PMID: 27915383
The structure of the human A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a...
9.
Xia L, de Vries H, Ijzerman A, Heitman L
Purinergic Signal
. 2015 Dec;
12(1):115-26.
PMID: 26647040
Scintillation proximity assay (SPA) is a radio-isotopic technology format used to measure a wide range of biological interactions, including drug-target binding affinity studies. The assay is homogeneous in nature, as...
10.
Peeters M, Fokkelman M, Boogaard B, Egerod K, van de Water B, Ijzerman A, et al.
Cell Signal
. 2015 Sep;
27(12):2579-88.
PMID: 26321231
Adhesion G protein-coupled receptors (ADGRs) are believed to be activated by auto-proteolytic cleavage of their very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively...