Aaron J Marcus
Overview
Explore the profile of Aaron J Marcus including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
650
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Recent Articles
1.
Krieger A, Anand R, Hernandez-Rosa E, Maidman A, Milrad S, DeGrazia M, et al.
Sleep Breath
. 2020 Feb;
24(4):1537-1547.
PMID: 32036486
Purpose: Obstructive sleep apnea (OSA) is independently associated with increased risk for stroke and other cardiovascular diseases. Since activated platelets play an important role in cardiovascular disease, the objective of...
2.
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson K, et al.
FASEB J
. 2014 Oct;
29(1):61-9.
PMID: 25318477
Ischemia/reperfusion (I/R) elicits renin release from cardiac mast cells (MC), thus activating a local renin-angiotensin system (RAS), culminating in ventricular fibrillation. We hypothesized that in I/R, neurogenic ATP could degranulate...
3.
Moeckel D, Jeong S, Sun X, Broekman M, Nguyen A, Drosopoulos J, et al.
Sci Transl Med
. 2014 Aug;
6(248):248ra105.
PMID: 25100739
In patients with acute myocardial infarction undergoing reperfusion therapy to restore blood flow through blocked arteries, simultaneous inhibition of platelet P2Y12 receptors with the current standard of care neither completely...
4.
Marcus A
Blood
. 2012 Apr;
119(15):3378-9.
PMID: 22500052
In a highly interesting, intricate, and novel paper in this issue of Blood, Fung and colleagues have extended their previous pioneering studies and now reveal that molecules such as ATP...
5.
Pulte D, Furman R, Broekman M, Drosopoulos J, Ballard H, Olson K, et al.
Clin Lymphoma Myeloma Leuk
. 2011 Aug;
11(4):367-72.
PMID: 21816376
Introduction: Chronic lymphocytic leukemia (CLL) is a B-cell disorder, but it is also associated with abnormalities in T-lymphocyte function. In this study we examine changes in T-lymphocyte CD39 and CD73...
6.
Corti F, Olson K, Marcus A, Levi R
J Pharmacol Exp Ther
. 2011 Feb;
337(2):524-32.
PMID: 21325440
Once released, norepinephrine is removed from cardiac synapses via reuptake into sympathetic nerves, whereas transmitter ATP is catabolized by ecto-NTP diphosphohydrolase 1 (E-NTPDase1)/CD39, an ecto-ATPase. Because ATP is known to...
7.
He K, Sui G, Xiong H, Broekman M, Huang B, Marcus A, et al.
J Biol Chem
. 2010 Dec;
286(17):15428-39.
PMID: 21115493
In response to blood vessel injury, hemostasis is initiated by platelet activation, advanced by thrombin generation, and tempered by fibrinolysis. The primary fibrinolytic protease, plasmin, can be activated either on...
8.
Jacovina A, Deora A, Ling Q, Broekman M, Almeida D, Greenberg C, et al.
J Clin Invest
. 2009 Oct;
119(11):3384-94.
PMID: 19841537
When plasma levels of homocysteine (HC), a thiol amino acid formed upon methionine demethylation, exceed 12 muM, individuals are at increased risk of developing large vessel atherothrombosis and small vessel...
9.
Fung C, Marcus A, Broekman M, Mahaut-Smith M
Trends Cardiovasc Med
. 2009 May;
19(1):1-5.
PMID: 19467446
Thrombus formation at sites of disrupted atherosclerotic plaques is a leading cause of death and disability worldwide. Although the platelet is now recognized to be a central regulator of thrombus...
10.
Hyman M, Petrovic-Djergovic D, Visovatti S, Liao H, Yanamadala S, Bouis D, et al.
J Clin Invest
. 2009 Apr;
119(5):1136-49.
PMID: 19381014
Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP to suppress platelet accumulation in the ischemic...