Joan H F Drosopoulos
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Explore the profile of Joan H F Drosopoulos including associated specialties, affiliations and a list of published articles.
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14
Citations
347
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Recent Articles
1.
Krieger A, Anand R, Hernandez-Rosa E, Maidman A, Milrad S, DeGrazia M, et al.
Sleep Breath
. 2020 Feb;
24(4):1537-1547.
PMID: 32036486
Purpose: Obstructive sleep apnea (OSA) is independently associated with increased risk for stroke and other cardiovascular diseases. Since activated platelets play an important role in cardiovascular disease, the objective of...
2.
Moeckel D, Jeong S, Sun X, Broekman M, Nguyen A, Drosopoulos J, et al.
Sci Transl Med
. 2014 Aug;
6(248):248ra105.
PMID: 25100739
In patients with acute myocardial infarction undergoing reperfusion therapy to restore blood flow through blocked arteries, simultaneous inhibition of platelet P2Y12 receptors with the current standard of care neither completely...
3.
Pulte D, Furman R, Broekman M, Drosopoulos J, Ballard H, Olson K, et al.
Clin Lymphoma Myeloma Leuk
. 2011 Aug;
11(4):367-72.
PMID: 21816376
Introduction: Chronic lymphocytic leukemia (CLL) is a B-cell disorder, but it is also associated with abnormalities in T-lymphocyte function. In this study we examine changes in T-lymphocyte CD39 and CD73...
4.
Pulte E, Broekman M, Olson K, Drosopoulos J, Kizer J, Islam N, et al.
Thromb Res
. 2007 Jun;
121(3):309-17.
PMID: 17555802
Introduction: CD39/NTPDase-1 is a cell surface enzyme expressed on leukocytes and endothelial cells that metabolizes ATP to ADP and AMP. CD39 is expressed on numerous different types of normal leukocytes,...
5.
Musi E, Islam N, Drosopoulos J
Arch Biochem Biophys
. 2007 Mar;
461(1):30-9.
PMID: 17374358
Human CD39/NTPDase1 is an endothelial cell membrane-associated nucleotidase. Its large extracellular domain rapidly metabolizes nucleotides, especially ADP released from activated platelets, inhibiting further platelet activation/recruitment. Previous studies using our recombinant...
6.
El-Omar M, Islam N, Broekman M, Drosopoulos J, Roa D, Lorin J, et al.
Thromb Res
. 2005 Jun;
116(3):199-206.
PMID: 15935828
Introduction: CD39 (NTPDase1), an endothelial cell membrane glycoprotein, is the predominant ATP diphosphohydrolase (ATPDase) in vascular endothelium. It hydrolyses both triphosphonucleosides and diphosphonucleosides at comparable rates, thus terminating platelet aggregation...
7.
Marcus A, Broekman M, Drosopoulos J, Olson K, Islam N, Pinsky D, et al.
Semin Thromb Hemost
. 2005 Apr;
31(2):234-46.
PMID: 15852226
Blood platelets maintain vascular integrity and promote primary and secondary hemostasis following interruption of vessel continuity. Biochemical or physical damage to coronary, carotid, or peripheral arteries promotes excessive platelet activation...
8.
Marcus A, Broekman M, Drosopoulos J, Islam N, Pinsky D, Sesti C, et al.
J Pharmacol Exp Ther
. 2003 Mar;
305(1):9-16.
PMID: 12649347
Platelets are responsible for maintaining vascular integrity. In thrombocytopenic states, vascular permeability and fragility increase, presumably due to the absence of this platelet function. Chemical or physical injury to a...
9.
Wood E, Broekman M, Kirley T, Diani-Moore S, Tickner M, Drosopoulos J, et al.
Arch Biochem Biophys
. 2002 Oct;
407(1):49-62.
PMID: 12392715
We report here that induction of ectoATPase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is cell-type specific and not a generalized response to aryl hydrocarbon (Ah) receptor activation. TCDD increased [14C]-ATP and -ADP metabolism...
10.
Birk A, Broekman M, Gladek E, Robertson H, Drosopoulos J, Marcus A, et al.
J Lab Clin Med
. 2002 Sep;
140(3):166-75.
PMID: 12271274
Extracellular adenosine triphosphate (ATP) regulates platelet reactivity by way of direct action on platelet purinergic receptors or by hydrolysis to adenosine diphosphate (ADP). Subsequent metabolism of ATP and ADP to...