A T Sim
Overview
Explore the profile of A T Sim including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
29
Citations
758
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0
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Recent Articles
1.
Michell B, Chen Zp , Tiganis T, Stapleton D, Katsis F, Power D, et al.
J Biol Chem
. 2001 Apr;
276(21):17625-8.
PMID: 11292821
Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production of NO from arginine. Multiple protein kinases including Akt/PKB, cAMP-dependent protein kinase (PKA), and...
2.
Schillace R, Voltz J, Sim A, Shenolikar S, Scott J
J Biol Chem
. 2001 Jan;
276(15):12128-34.
PMID: 11152471
The phosphorylation status of cellular proteins is controlled by the opposing actions of protein kinases and phosphatases. Compartmentalization of these enzymes is critical for spatial and temporal control of these...
3.
McCuskey A, Keane M, Mudgee L, Sim A, Sakoff J, Quinn R
Eur J Med Chem
. 2000 Dec;
35(10):957-64.
PMID: 11121622
A series of anhydride modified cantharidin analogues have been synthesised and screened for their ability to inhibit protein phosphatase 2A. Surprisingly only analogues capable of undergoing a facile ring opening...
4.
Lengyel I, Hall A, Sim A, Rostas J, Dunkley P
J Neurochem
. 2000 Jul;
75(2):594-605.
PMID: 10899934
Calcium/calmodulin-dependent protein kinase II (CaMPK-II) is a key regulatory enzyme in living cells. Modulation of its activity, therefore, could have a major impact on many cellular processes. We found that...
5.
Ludowyke R, Holst J, Mudge L, Sim A
J Biol Chem
. 2000 Feb;
275(9):6144-52.
PMID: 10692405
Okadaic acid inhibits secretion from mast cells, suggesting a regulatory role for protein Ser/Thr phosphatases type I (PP1) and/or 2A (PP2A) in the secretory process. In unstimulated RBL-2H3 cells, okadaic...
6.
Sim A, Scott J
Cell Calcium
. 2000 Jan;
26(5):209-17.
PMID: 10643559
The intracellular responses to many distinct extracellular signals involve the direction of broad-based protein kinases and protein phosphatases to catalyse quite specific protein phosphorylation/dephosphorylation events. It is now clear that...
7.
8.
Sim A, Collins E, Mudge L, Rostas J
Neurochem Res
. 1998 May;
23(4):487-91.
PMID: 9566582
The activity and subcellular distribution of protein phosphatases 1 and 2A were measured in chicken forebrain and cerebellum during post-hatch development. At all post-hatch ages, a large proportion of PP1...
9.
Goncalves C, Hall A, Sim A, Bunn S, Marley P, Cheah T, et al.
J Neurochem
. 1997 Dec;
69(6):2387-96.
PMID: 9375670
The protein kinases and protein phosphatases that act on tyrosine hydroxylase in vivo have not been established. Bovine adrenal chromaffin cells were permeabilized with digitonin and incubated with [gamma-32P]ATP, in...
10.
Brent P, Herd L, Saunders H, Sim A, Dunkley P
J Neurochem
. 1997 May;
68(5):2201-11.
PMID: 9109549
The sigma ligand 1,3-di-O-tolylguanidine (DTG) increased basal dynamin and decreased depolarization-stimulated phosphorylation of the synaptosomal protein synapsin Ib without having direct effects on protein kinases or protein phosphatases. DTG dose-dependently...