D G Hardie
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Explore the profile of D G Hardie including associated specialties, affiliations and a list of published articles.
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Articles
151
Citations
9179
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Recent Articles
1.
Rog-Zielinska E, Craig M, Manning J, Richardson R, Gowans G, Dunbar D, et al.
Cell Death Differ
. 2014 Nov;
22(7):1106-16.
PMID: 25361084
Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise survival. Cardiomyocyte glucocorticoid receptor (GR) is required for the...
2.
Hadad S, Hardie D, Appleyard V, Thompson A
Clin Transl Oncol
. 2013 Dec;
16(8):746-52.
PMID: 24338509
Aim: The aim of this study was to compare the effects and mechanisms of action of metformin on estrogen receptor (ER)-positive and ER-negative breast cancer cell lines. Methods: The anti-proliferative...
3.
Hardie D
Cold Spring Harb Symp Quant Biol
. 2011 Nov;
76:155-64.
PMID: 22071265
Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor activated by metabolic stresses that inhibit catabolic ATP production or accelerate ATP consumption. Once activated, AMPK switches on catabolic pathways,...
4.
Jamieson P, Cleasby M, Kuperman Y, Morton N, Kelly P, Brownstein D, et al.
Diabetologia
. 2011 Jun;
54(9):2392-403.
PMID: 21667214
Aims/hypothesis: Urocortins are the endogenous ligands for the corticotropin-releasing factor receptor type 2 (CRFR2), which is implicated in regulating energy balance and/or glucose metabolism. We determined the effects of chronic...
5.
Fogarty S, Hardie D
Biochim Biophys Acta
. 2009 Sep;
1804(3):581-91.
PMID: 19778642
AMP-activated protein kinase (AMPK) is a cellular energy sensor activated by metabolic stresses that either inhibit ATP synthesis or accelerate ATP consumption. Activation of AMPK in response to an increase...
6.
Dallas M, Scragg J, Wyatt C, Ross F, Hardie D, Evans A, et al.
Adv Exp Med Biol
. 2009 Jun;
648:57-63.
PMID: 19536465
Hypoxic inhibition of K(+) channels in type I cells is believed to be of central importance in carotid body chemotransduction. We have recently suggested that hypoxic channel inhibition is mediated...
7.
Treebak J, Frosig C, Pehmoller C, Chen S, Maarbjerg S, Brandt N, et al.
Diabetologia
. 2009 Mar;
52(5):891-900.
PMID: 19252894
Aims/hypothesis: TBC1 domain family, member 4 (TBC1D4; also known as AS160) is a cellular signalling intermediate to glucose transport regulated by insulin-dependent and -independent mechanisms. Skeletal muscle insulin sensitivity is...
8.
McBride A, Hardie D
Acta Physiol (Oxf)
. 2009 Feb;
196(1):99-113.
PMID: 19245651
The classical role of the AMP-activated protein kinase (AMPK) is to act as a sensor of the immediate availability of cellular energy, by monitoring the concentrations of AMP and ATP....
9.
Hardie D
Int J Obes (Lond)
. 2008 Sep;
32 Suppl 4:S7-12.
PMID: 18719601
The AMP-activated protein kinase (AMPK) system is a key player in regulating energy balance at both the cellular and whole-body levels, placing it at centre stage in studies of obesity,...
10.
Mooney M, Fogarty S, Stevenson C, Gallagher A, Palit P, Hawley S, et al.
Br J Pharmacol
. 2008 Feb;
153(8):1669-77.
PMID: 18297106
Background And Purpose: Galegine and guanidine, originally isolated from Galega officinalis, led to the development of the biguanides. The weight-reducing effects of galegine have not previously been studied and the...