A J Coyle
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Explore the profile of A J Coyle including associated specialties, affiliations and a list of published articles.
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69
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2489
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Recent Articles
11.
Gajewska B, Alvarez D, Vidric M, Goncharova S, Stampfli M, Coyle A, et al.
J Clin Invest
. 2001 Aug;
108(4):577-83.
PMID: 11518731
The objective of this study was to investigate the contribution of secondary lymphoid organs in the generation and maintenance of experimental allergic airway inflammation. We employed a previously reported murine...
12.
Rottman J, Smith T, Tonra J, Ganley K, Bloom T, Silva R, et al.
Nat Immunol
. 2001 Jun;
2(7):605-11.
PMID: 11429544
The inducible costimulatory molecule (ICOS) is expressed on activated T cells and participates in a variety of important immunoregulatory functions. After the induction of experimental allergic encephalomyelitis in SJL mice...
13.
Gonzalo J, Tian J, Delaney T, Corcoran J, Rottman J, Lora J, et al.
Nat Immunol
. 2001 Jun;
2(7):597-604.
PMID: 11429543
We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were...
14.
Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos J, Amaral J, et al.
Nat Immunol
. 2001 Jun;
2(7):591-6.
PMID: 11429542
Primary T cell activation requires B7-CD28 and CD40-CD154 costimulation, but effector T cell functions are considered to be largely independent of these costimulatory pathways. Although blockade of costimulation with cytolytic...
15.
Trifilieff A, Fujitani Y, Coyle A, Kopf M, Bertrand C
Clin Exp Allergy
. 2001 Jun;
31(6):934-42.
PMID: 11422160
Background And Objectives: Lung remodelling is a recognized feature of chronic asthma. In the present study, we have used IL-5-deficient mice to evaluate the role of this cytokine and eosinophilic...
16.
Lloyd C, Gonzalo J, Coyle A, Gutierrez-Ramos J
Adv Immunol
. 2001 Apr;
77:263-95.
PMID: 11293118
No abstract available.
17.
Walzl G, Matthews S, Kendall S, Gutierrez-Ramos J, Coyle A, Openshaw P, et al.
J Exp Med
. 2001 Apr;
193(7):785-92.
PMID: 11283151
T cells secreting interleukin (IL)-4 and IL-5 (T helper cell type 2 [Th2] cells) play a detrimental role in a variety of diseases, but specific methods of regulating their activity...
18.
Coyle A, Gutierrez-Ramos J
Nat Immunol
. 2001 Feb;
2(3):203-9.
PMID: 11224518
Upon encounter with specific antigen, naïveT helper precursor (THP) cells become activated. This event is regulated not only by engagement of the T cell receptor (TCR) with peptide presented in...
19.
Stanciu L, Roberts K, Lau L, Coyle A, Johnston S
Int Immunol
. 2001 Feb;
13(3):341-8.
PMID: 11222503
Repeated administration or chronic presence of antigen during CD4(+) T cell activation and a cytokine milieu enriched in IL-4 favour the generation and maintenance of a T(h)2 population. However, there...
20.
Meisel C, Bonhagen K, Lohning M, Coyle A, Gutierrez-Ramos J, Radbruch A, et al.
J Immunol
. 2001 Feb;
166(5):3143-50.
PMID: 11207266
The orphan receptor T1/ST2, a member of the IL-1R family, is preferentially expressed on the surface of murine Th2 cells. In this study, we analyzed the kinetics and function of...