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C M Lloyd

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Articles 66
Citations 1734
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Recent Articles
1.
Albers G, Iwasaki J, McErlean P, Ogger P, Ghai P, Khoyratty T, et al.
Clin Exp Immunol . 2021 Jan; 204(1):134-143. PMID: 33423291
Interferon regulatory factor 5 (IRF5) is a master regulator of macrophage phenotype and a key transcription factor involved in expression of proinflammatory cytokine responses to microbial and viral infection. Here,...
2.
Snelgrove R, Patel D, Patel T, Lloyd C
Clin Exp Allergy . 2018 Jun; 48(10):1275-1285. PMID: 29900603
Whilst severe asthma has classically been categorized as a predominantly Th2-driven pathology, there has in recent years been a paradigm shift with the realization that it is a heterogeneous disease...
3.
Denney L, Branchett W, Gregory L, Oliver R, Lloyd C
Mucosal Immunol . 2017 Oct; 11(2):523-535. PMID: 29067998
Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells have a vital...
4.
Weiss G, Lai C, Fife M, Grabiec A, Tildy B, Snelgrove R, et al.
Mucosal Immunol . 2016 Dec; 10(4):1021-1030. PMID: 27966555
Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on neutrophils and monocyte/macrophages and amplifies Toll-like receptor-mediated inflammation during infection. TREM-1 also exists in an antagonistic soluble form (sTREM-1) that...
5.
Byrne A, Weiss M, Mathie S, Walker S, Eames H, Saliba D, et al.
Mucosal Immunol . 2016 Oct; 10(3):716-726. PMID: 27759022
Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of the expression of proinflammatory cytokine and responses to infection, but its role in regulating pulmonary...
6.
Mathie S, Dixon K, Walker S, Tyrrell V, Mondhe M, ODonnell V, et al.
Allergy . 2014 Oct; 70(1):80-9. PMID: 25331546
Background: Alveolar macrophages are sentinels of the pulmonary mucosa and central to maintaining immunological homeostasis. However, their role in governing the response to allergen is not fully understood. Inappropriate responses...
7.
Murdoch J, Gregory L, Lloyd C
Clin Exp Allergy . 2014 Aug; 44(11):1386-98. PMID: 25146585
Background: γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of...
8.
Vasiliou J, Lui S, Walker S, Chohan V, Xystrakis E, Bush A, et al.
Allergy . 2014 Jun; 69(10):1380-9. PMID: 24943330
Background: Associations between vitamin D status and childhood asthma are increasingly reported, but direct causation and mechanisms underlying an effect remain unknown. We investigated the effect of early-life vitamin D...
9.
Gregory L, Jones C, Mathie S, Pegorier S, Lloyd C
Allergy . 2013 Oct; 68(12):1579-88. PMID: 24117726
Background: The current paradigm describing asthma pathogenesis recognizes the central role of abnormal epithelial function in the generation and maintenance of the disease. However, the mechanisms responsible for the initiation...
10.
Moldaver D, Bharhani M, Wattie J, Ellis R, Neighbour H, Lloyd C, et al.
Mucosal Immunol . 2013 Aug; 7(2):379-90. PMID: 23945544
In the present study, we show therapeutic amelioration of established ovalbumin (OVA)-induced allergic airway disease following house dust mite (HDM) peptide therapy. Mice were sensitized and challenged with OVA and...