Alteration of Clonal Profile. I. Effect of Sublethal Irradiation on the Responses to Phosphorylcholine in BALB/c Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1978 Oct 1

PMID 702066

Citations 1

Authors

D R Kaplan

J Quintans

Affiliations

Soon will be listed here.

Abstract

BALB/c mice exhibit greater than 90% H8 clonal dominance in the immune response to phosphorylcholine. Adult mice exposed to 500 rads were initally unable to produce a humoral immune response to both phosphorylcholine and trinitrophenol antigens, and the direct plaque-forming cell response was slowly regained over several weeks. Clonotypic analysis wity antisera directed against the H8 idiotype showed that the H8 clone initially dominated the recovery of the response to phosphorycholine but that 60 days after the irradiation significant numbers of non-H8 clones could be detected. This same pattern could be seen in mice irradiated with 100 rads, a dose that does not completely abrogate the H8 response to phosphorylcholine. Sublethal irradiation of neonates before they had acquired responsiveness to phosphorylcholine could also eventually lead to the emergence of non-H8 idiotypes. Thus, a radiosensitive element regulates the expression of clonal dominance in anti-phosphorylcholine responses of BALB/c mice.

Citing Articles

Alteration of clonal profile. III. T15 ontogenetic advantages are not sufficient for establishing idiotypic dominance in adoptive transfer.

Quan Z, Quintans J J Exp Med. 1981; 154(5):1475-88.

PMID: 6975348 PMC: 2186510. DOI: 10.1084/jem.154.5.1475.

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