Specific Inhibition of Plaque Formation to Phosphorylcholine by Antibody Against Antibody

Overview

Journal Science

Specialty Science

Date 1972 Jun 2

PMID 4113485

Citations 57

Authors

H Cosenza

H Kohler

Affiliations

Soon will be listed here.

Abstract

Spleen cells from BALB/c mice immunized with heat-killed rough pneumococci (strain R36A) or spleen cells from normal mice immunized in vitro with the same antigen produce direct hemolytic plaques against sheep erythrocytes coated with pneumococcal C polysaccharide or conjugated with phosphorylcholine. Formation of plaques is specifically inhibited by phosphorylcholine or by antiserum to mouse immunoglobulin A myeloma protein which binds phosphorylcholine. Thus, the myeloma proteins and normal BALB/c antibodies share similar idiotypic determinants. This experimental system is suitable for probing the role of the antigen receptor in the immune response.

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