Clonal Nature of the Immune Response to Phosphorylcholine. IV. Idiotypic Uniformity of Binding Site-associated Antigenic Determinants Among Mouse Antiphosphorylcholine Antibodies

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1974 Sep 1

PMID 4137581

Citations 35

Authors

J L CLAFLIN

J M Davie

Affiliations

Soon will be listed here.

Abstract

A new idiotypic determinant(s) on mouse anti-PC antibodies is described. Antibodies to the determinant(s) were raised in rabbits by immunization with HOPC 8, a PC-binding myeloma protein, and were isolated from HOPC 8 immunoadsorbent by elution with PC. These antibodies react with binding site determinants on anti-PC antibodies raised in all 15 inbred mouse strains tested regardless of histocompatibility or allotype, but fail to react with antibodies of other specificities or with anti-PC antibodies raised in other rodent species. These results correlate closely with other studies which show similar binding specificity of anti-PC antibodies raised in 17 different strains of mice. The site-associated idiotypic determinant(s) is clearly distinct from that detected by mouse anti-HOPC 8 antisera. This latter determinant(s) is present on anti-PC antibodies of only a few strains of mice and may not be in the binding site.

Citing Articles

Somatically generated mouse myeloma variants synthesizing IgA half-molecules.

Zack D, Morrison S, Cook W, Dackowski W, Scharff M J Exp Med. 1981; 154(5):1554-69.

PMID: 7299348 PMC: 2186520. DOI: 10.1084/jem.154.5.1554.

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

Briles D, Nahm M, Schroer K, Davie J, Baker P, Kearney J J Exp Med. 1981; 153(3):694-705.

PMID: 7252411 PMC: 2186108. DOI: 10.1084/jem.153.3.694.

Recurrent idiotopes and internal images.

Jerne N, Roland J, Cazenave P EMBO J. 1982; 1(2):243-7.

PMID: 6985352 PMC: 553027. DOI: 10.1002/j.1460-2075.1982.tb01154.x.

Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies.

Gleason K, Kohler H J Exp Med. 1982; 156(2):539-49.

PMID: 6808074 PMC: 2186772. DOI: 10.1084/jem.156.2.539.

Nucleic acid and protein sequences of phosphocholine-binding light chains.

Kwan S, Rudikoff S, Seidman J, Leder P, Scharff M J Exp Med. 1981; 153(5):1366-70.

PMID: 6788890 PMC: 2186162. DOI: 10.1084/jem.153.5.1366.

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