Erythrocytes in Human Transplantation: Effects of Pretreatment with ABO Group-specific Antigens

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1968 Oct 1

PMID 4877681

Citations 5

Authors

F T RAPAPORT

J Dausset

L Legrand

A Barge

H S LAWRENCE

J M CONVERSE

Affiliations

Soon will be listed here.

Abstract

Erythrocyte group antigens A and B can act as potent and group-specific transplantation antigens in man. ABO group-incompatible recipients pretreated with such antigens have rejected skin allografts obtained from donors incompatible for the same antigens in an accelerated (4-5 days) or white graft manner. Skin grafts applied to the same recipients from ABO-compatible donors were accorded first-set survival times. Intact erythrocyte suspensions and antigens isolated from hog (A substance) and horse (B substance) stomachs, were equally capable of inducing this type of allograft sensitivity. The latter observation broadens the spectrum of heterologous antigens capable of inducing allograft sensitivity in the mammalian host and provides a readily available, heat-stable, and water-soluble source of antigens for further studies of allograft rejection mechanisms in man.

Citing Articles

History of clinical transplantation.

Starzl T World J Surg. 2000; 24(7):759-82.

PMID: 10833242 PMC: 3091383. DOI: 10.1007/s002680010124.

The biological basis of and strategies for clinical xenotransplantation.

Starzl T, Valdivia L, Murase N, Demetris A, Fontes P, Rao A Immunol Rev. 1994; 141:213-44.

PMID: 7868154 PMC: 3005617. DOI: 10.1111/j.1600-065x.1994.tb00879.x.

Hyperacute rejection of renal homografts: with particular reference to coaglation changes, humoral antibodies, and formed blood elements.

BOEHMIG H, Giles G, Amemiya H, Wilson C, Coburg A, Genton E Transplant Proc. 1971; 3(2):1105-17.

PMID: 4944050 PMC: 2840626.

Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping.

STICKEL D, Seigler H, Amos D, Ward F, GUNNELLS Jr J, Price A Ann Surg. 1970; 172(2):160-79.

PMID: 4914816 PMC: 1397062. DOI: 10.1097/00000658-197008000-00002.

The definition of ABO factors in transplantation: relation to other humoral antibody states.

Starzl T, Tzakis A, Makowka L, Banner B, Demetrius A, Ramsey G Transplant Proc. 1987; 19(6):4492-7.

PMID: 3321606 PMC: 2987702.

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