The Bacterial Induction of Homograft Sensitivity. I. Effects of Sensitization with Group A Streptococci

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1965 Oct 1

PMID 5321602

Citations 14

Authors

R M CHASE Jr

F T RAPAPORT

Affiliations

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Abstract

Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. The gross and histologic appearance of these grafts is identical with that observed in similar reactions obtained in guinea pigs sensitized with homologous tissues. The ability of Group A hemolytic streptococci to induce homograft sensitivity in the guinea pig is a property shared by Types 4, 5, 6, 11, 12, 14, and 49 of Group A streptococci.

Citing Articles

Application of enzyme production properties in subtyping of group A streptococci according to T type.

Ofek I, Fleiderman S, BERGNER-RABINOWITZ S, GINSBERG I Appl Microbiol. 1971; 22(5):748-51.

PMID: 5167211 PMC: 376410. DOI: 10.1128/am.22.5.748-751.1971.

Erythrocytes in human transplantation: effects of pretreatment with ABO group-specific antigens.

RAPAPORT F, Dausset J, Legrand L, Barge A, LAWRENCE H, CONVERSE J J Clin Invest. 1968; 47(10):2206-16.

PMID: 4877681 PMC: 297385. DOI: 10.1172/JCI105906.

Heterotopic liver transplantation utilizing inbred rat strains. I. Characterization of allogeneic graft rejection and the effects of biliary obstruction and portal vein circulation on liver regeneration.

Lee S, Edgington T Am J Pathol. 1968; 52(3):649-69.

PMID: 4868325 PMC: 2013425.

Accelerated rejection of rat allografts after the rejection of rabbit skin grafts.

Brautbar C, Nelken D Clin Exp Immunol. 1967; 2(6):691-5.

PMID: 4866460 PMC: 1578804.

Heterophile antibodies in human transplantation.

RAPAPORT F, Kano K, Milgrom F J Clin Invest. 1968; 47(3):633-42.

PMID: 4866325 PMC: 297209. DOI: 10.1172/JCI105759.

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