The Definition of ABO Factors in Transplantation: Relation to Other Humoral Antibody States

Overview

Journal Transplant Proc

Specialty General Surgery

Date 1987 Dec 1

PMID 3321606

Citations 15

Authors

T E Starzl

A Tzakis

L Makowka

B Banner

A Demetrius

G Ramsey

R Duquesnoy

M Griffin

Affiliations

Soon will be listed here.

Abstract

The first examples of hyperacute rejection of renal hemografts were seen almost 25 years ago when kidneys were transplanted to ABO incompatible recipients whose plasma contained antigraft isoagglutinins. Hyperacute rejection caused in sensitized recipients by lymphocytotoxic antibodies is similar in that the immune reaction triggers an acute inflammatory reaction that leads to widespread thrombotic occlusion and devascularization of the graft. The events after xenotransplantation between certain species are essentially the same. Potential strategies to avoid the precipitating antigen antibody reaction or to mitigate the resulting effector cascade are described.

Citing Articles

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Strategies to overcome the ABO barrier in kidney transplantation.

Bohmig G, Farkas A, Eskandary F, Wekerle T Nat Rev Nephrol. 2015; 11(12):732-47.

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Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells.

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