IgM-producing Tumors in the BALB-c Mouse: a Model for B-cell Maturation

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1974 Sep 1

PMID 4606641

Citations 16

Authors

J Andersson

J Buxbaum

R Citronbaum

S Douglas

L Forni

F Melchers

B Pernis

D Stott

Affiliations

Soon will be listed here.

Abstract

Five adjuvant induced BALB/c tumors producing IgM-McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781-were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10-25-h stimulated normal B cells, 3469 cells resemble 20-35-h stimulated B cells, TEPC 183 cells resemble 45-65-h stimulated B cells, Y 5781 cells resemble 80-110-h stimulated B cells, and McPc 774 cells resemble 100-130-h stimulated B cells.

Citing Articles

Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis.

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Surface receptors on lymphoreticular cells: sensory devices for host recognition of foreign antigens and neoplasia.

Elliott B, Kerbel R, Nagy Z Can Med Assoc J. 1980; 122(12):1361-72.

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Long-term culture of B lymphocytes and their precursors from murine bone marrow.

Whitlock C, Witte O Proc Natl Acad Sci U S A. 1982; 79(11):3608-12.

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Amplification of a specific set of intracisternal A-particle genes in a mouse plasmacytoma.

Cole M J Virol. 1984; 49(1):171-7.

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Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

Pattengale P, Taylor C Am J Pathol. 1983; 113(2):237-65.

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