Immunoglobulin Synthesis by Neoplastic Cells: Models of a Clonal Transition from IgM to IgG Synthesis

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1980 Jun 1

PMID 7400356

Citations 2

Authors

J Gordon

J L Smith

Affiliations

Soon will be listed here.

Abstract

Tumour populations from two B cell neoplasms were investigated for their capacity to synthesise immunoglobulin in vitro. Neoplastic cells from a patient with chronic lymphocytic leukaemia and an IgG lambda paraproteinaemia co-expressed surface IgG lambda and IgM lambda and synthesised both IgG lambda and IgM lambda in short-term culture. In the second patient with non-Hodgkin's lymphoma, the neoplastic cells expressed surface IgM lambda but synthesised both IgM lambda and IgG lambda in vitro. The findings are discussed in terms of a model for the clonal switch from IgM to IgG synthesis.

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