Immunological Study of Carcinoembryonic Antigen (CEA) and a Related Glycoprotein

Overview

Journal Br J Cancer

Specialty Oncology

Date 1973 Aug 1

PMID 4199743

Citations 23

Authors

D A DARCY

C Turberville

R James

Affiliations

Soon will be listed here.

Abstract

A comparison has been made of the immunological properties of CEA (carcinoembryonic antigen) and another perchloric acid-soluble macromolecule which occurs in colonic and certain other carcinomata and which is here termed CEX. By using a variety of antisera it was shown that the two substances share common antigenic groups as well as having characteristic ones of their own. These latter groups have enabled the preparation of (a) antisera which give a gel diffusion line only with CEA and (b) and antiserum which gives a line only with CEX. No immunological difference could be found between CEX and the NGP of Mach or the NCA of von Kleist and Burtin. CEX was found in foetal gut, in plasma and associated with CEA in virtually all the tissues and fluids in which the latter occurs; the two appear to go hand-in-hand and no proof was found that CEX is either less or more cancer specific than CEA-it is merely found in greater quantity; neither substance showed absolute cancer specificity. The usefulness of a radioimmunoassay for CEX is discussed, and also the possibility of interference by CEX in the radioimmunoassay for CEA. Evidence of two molecular species of CEA has been found.

Citing Articles

Further investigations of immunoreactive carcinoembryonic antigen (CEA) in colorectal cancer patients--with particular emphasis on the correlation between immunoreactive CEA levels in tissue, feces and blood.

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An investigation of factors influencing serum NCA (non-specific cross-reacting antigen) level in patients with chronic myeloid leukaemia.

Frenoy N, Berruel C, Child J, Gendron M, Missett J, Razafimahaleo E Br J Cancer. 1982; 46(5):765-72.

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Carcinoembryonic antigen-like substances of human urothelial carcinomas. Isolation of components from pathological urine and comparison with colorectal carcinoma antigens.

Nery R, Barsoum A, Bullman H, Neville A Biochem J. 1974; 139(2):431-40.

PMID: 4475593 PMC: 1166300. DOI: 10.1042/bj1390431.

Aspects of the structure and clinical role of the carcinoembryonic antigen (CEA) and related macromolecules with particular reference to urothelial carcinoma.

Neville A, Nery R, Hall R, Turberville C, Laurence D Br J Cancer Suppl. 1973; 1:198-207.

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Clinical value of tumour-associated antigens.

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