A Monkey Antigen Crossreacting with Carcinoembryonic Antigen, CEA

Overview

Journal Br J Cancer

Specialty Oncology

Date 1976 Oct 1

PMID 823952

Citations 2

Authors

E Engvall

M Vuento

E Ruoslahti

Affiliations

Soon will be listed here.

Abstract

Normal monkey tissues were found to contain an antigen which crossreacts immunologically with the carcinoembryonic antigen (CEA) of the human digestive tract. The monkey antigen reacted with complete or partial identity to the normal crossreacting antigen (NCA) in humans when tested in immunodiffusion against anti-CEA or anti-NCA. Extracts of monkey tissues inhibited in radioimmunoassays measuring human NCA. It is possible that monkey foetuses and colonic tumours contain CEA.

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Isolation and characterization of the normal crossreacting antigen: homology of its NH2-terminal amino acid sequence with that of carcinoembryonic antigen.

Engvall E, Shively J, Wrann M Proc Natl Acad Sci U S A. 1978; 75(4):1670-4.

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References

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