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Urinary Carcinoembryonic Antigen (CEA)-like Molecules and Urothelial Malignancy: a Clinical Appraisal

Overview
Journal Br J Cancer
Specialty Oncology
Date 1975 Feb 1
PMID 1164465
Citations 7
Authors
G B Coombers
R R Hall
J R Laurence
A M Neville
Affiliations
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Abstract

A total of 190 patients being treated or followed up for urothelial carcinoma have been studied by the serial estimation of their urinary and plasma CEA levels. Only 46% of patients with a urothelial neoplasm present have a raised urinary CEA level. Infection or ileal conduit urine vitiate the result as they produce high CEA levels in the urine in the absence of any neoplastic disease. The accuracy of urinary CEA estimations is compared with that of cytology. Plasma CEA levels do not serve as a useful guide to the presence of extra-urinary tract tumour spread if taken as isolated readings. However, serial plasma CEA estimations may indicate that metastatic disease is present several months before its detection by the more usual clinical methods in a minority of patients.

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Urine carcinoembryonic antigen levels are more useful than serum levels for early detection of Bilharzial and non-Bilharzial urinary bladder carcinoma: observations of 43 Egyptian cases.

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Carcinoembryonic antigen in serum, urine and cells of patients with bladder carcinoma.

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References
1.
Gold P, Freedman S . DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965; 121:439-62. PMC: 2137957. DOI: 10.1084/jem.121.3.439. View
2.
FOOT N, PAPANICOLAOU G, HOLMQUIST N, Seybolt J . Exfoliative cytology of urinary sediments; a review of 2,829 cases. Cancer. 1958; 11(1):127-37. DOI: 10.1002/1097-0142(195801/02)11:1<127::aid-cncr2820110124>3.0.co;2-w. View
3.
Thomson D, KRUPEY J, Freedman S, Gold P . The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969; 64(1):161-7. PMC: 286141. DOI: 10.1073/pnas.64.1.161. View
4.
Laurence D, Neville A . Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review. Br J Cancer. 1972; 26(5):335-55. PMC: 2008636. DOI: 10.1038/bjc.1972.45. View
5.
Neville A, Nery R, Hall R, Turberville C, Laurence D . Aspects of the structure and clinical role of the carcinoembryonic antigen (CEA) and related macromolecules with particular reference to urothelial carcinoma. Br J Cancer Suppl. 1973; 1:198-207. PMC: 2149056. View