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Studies of Colonic Carcinoma Antigens

Overview
Journal Gut
Specialty Gastroenterology
Date 1971 Jan 1
PMID 5543371
Citations 8
Authors
M S Kleinman
L Harwell
M D Turner
Affiliations
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Abstract

Extracts of human colonic adenocarcinomata were made with perchloric acid and shown to contain antigens which were not present in pooled samples of normal colonic mucosa or in healthy colonic mucosa from patients providing the tumours. Antisera prepared against the tumour extracts gave two precipitin lines on immunodiffusion, and antiserum prepared in Montreal according to the methods devised by Gold and Freedman (1965a and b) also gave two lines of precipitation when tested against some of these extracts; one of these precipitin lines gave a reaction of identity with that given by the antiserum produced here. The results suggest that perchloric acid may extract two antigens from colonic carcinomata.

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Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review.

Laurence D, Neville A Br J Cancer. 1972; 26(5):335-55.

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Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma.

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Aspects of the structure and clinical role of the carcinoembryonic antigen (CEA) and related macromolecules with particular reference to urothelial carcinoma.

Neville A, Nery R, Hall R, Turberville C, Laurence D Br J Cancer Suppl. 1973; 1:198-207.

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References
1.
Gold P, Freedman S . Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965; 122(3):467-81. PMC: 2138078. DOI: 10.1084/jem.122.3.467. View
2.
Paul W, Benacerraf B . Problems encountered in double diffusion analysis in agar of hapten specific immune systems. I. Complement dependent precipitation. J Immunol. 1965; 95(6):1067-73. View
3.
Paul W, Benacerraf B . Problems encountered in double diffusion analysis in agar of hapten specific immune systems. II. The effect of the relative solubility of the immune complexes formed by cross-reacting systems. J Immunol. 1965; 95(6):1074-9. View
4.
Gleich G, Allen P . Immunochemical studies on some immune systems involving beta-(1,4) linked glucose. Immunochemistry. 1965; 2(4):417-31. DOI: 10.1016/0019-2791(65)90040-6. View
5.
YACHI A, Matsuura Y, Carpenter C, Hyde L . Immunochemical studies on human lung cancer antigens soluble in 50 per cent saturated ammonium sulfate. J Natl Cancer Inst. 1968; 40(4):663-82. View