Group 2 Innate Lymphoid Cells Are a Non-redundant Source of Interleukin-5 Required for Development and Function of Murine B1 Cells

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Dec 5

PMID 39632879

Authors

Karoline F Troch

Manuel O Jakob

Patrycja M Forster

Katja J Jarick

Jonathan Schreiber

Alexandra Preusser

Gabriela M Guerra

Pawel Durek

Caroline Tizian

Nele Sterczyk

Sofia Helfrich

Claudia U Duerr

David Voehringer

Mario Witkowski

David Artis

Tim Rollenske

Andrey A Kruglov

Mir-Farzin Mashreghi

Christoph S N Klose

Affiliations

Soon will be listed here.

Abstract

Tissue-resident immune cells, such as innate lymphoid cells, mediate protective or detrimental immune responses at barrier surfaces. Upon activation by stromal or epithelial cell-derived alarmins, group 2 innate lymphoid cells (ILC2s) are a rapid source of type 2 cytokines, such as IL-5. However, due to the overlap in effector functions, it remains unresolved whether ILC2s are an essential component of the type 2 response or whether their function can be compensated by other cells, such as T cells. Here we show a non-redundant role of ILC2s in supporting the development and function of B1 cells. We demonstrate that B1 cells fail to develop properly in the absence of ILC2s and identify the IL-33 receptor on ILC2s as an essential cell-intrinsic regulator of IL-5 production. Further, conditional deletion of Il5 in ILC2s results in defective B1 cell development and immunoglobulin production. Consequently, B1 cells with phosphatidylcholine specific B cell receptor rearrangements are diminished in ILC2-deficient mice. Thus, our data establish an essential function of ILC2s in supporting B1 cells and antibody production at barrier surfaces.

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