Mario Witkowski
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Explore the profile of Mario Witkowski including associated specialties, affiliations and a list of published articles.
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19
Citations
722
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Recent Articles
1.
Goetzke C, Massoud M, Frischbutter S, Guerra G, Ferreira-Gomes M, Heinrich F, et al.
Nature
. 2025 Mar;
PMID: 40074901
In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C...
2.
Troch K, Jakob M, Forster P, Jarick K, Schreiber J, Preusser A, et al.
Nat Commun
. 2024 Dec;
15(1):10566.
PMID: 39632879
Tissue-resident immune cells, such as innate lymphoid cells, mediate protective or detrimental immune responses at barrier surfaces. Upon activation by stromal or epithelial cell-derived alarmins, group 2 innate lymphoid cells...
3.
Ferreira-Gomes M, Chen Y, Durek P, Rincon-Arevalo H, Heinrich F, Bauer L, et al.
Nat Commun
. 2024 May;
15(1):4182.
PMID: 38755157
Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their...
4.
Bondareva M, Budzinski L, Durek P, Witkowski M, Angermair S, Ninnemann J, et al.
Cell Host Microbe
. 2023 Nov;
31(11):1866-1881.e10.
PMID: 37944493
The commensal microflora provides a repertoire of antigens that illicit mucosal antibodies. In some cases, these antibodies can cross-react with host proteins, inducing autoimmunity, or with other microbial antigens. We...
5.
Lalia J, Schild R, Lutgehetmann M, Dunay G, Kallinich T, Kobbe R, et al.
Viruses
. 2023 Jul;
15(7).
PMID: 37515239
The situation of limited data concerning the response to COVID-19 mRNA vaccinations in immunocom-promised children hinders evidence-based recommendations. This prospective observational study investigated humoral and T cell responses after primary...
6.
Allers K, Moos V, Hofmann J, Witkowski M, Haibel H, Angermair S, et al.
Clin Immunol
. 2023 Jul;
254:109712.
PMID: 37506745
Little is known about the CD8 T cell functionality in the coronavirus disease 2019 (COVID-19). Therefore, we examined twenty-five hospitalized COVID-19 patients with moderate (MD) or severe disease (SD) as...
7.
Frischbutter S, Durek P, Witkowski M, Angermair S, Treskatsch S, Maurer M, et al.
Eur J Immunol
. 2023 Jun;
53(10):e2350433.
PMID: 37386908
For targeted intervention in coronavirus disease 2019 (COVID-19), there is a high medical need for biomarkers that predict disease progression and severity in the first days after symptom onset. This...
8.
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones T, Heinrich F, et al.
Nature
. 2021 Oct;
600(7888):295-301.
PMID: 34695836
SARS-CoV-2 is a single-stranded RNA virus that causes COVID-19. Given its acute and often self-limiting course, it is likely that components of the innate immune system play a central part...
9.
Witkowski M, Witkowski M, Friebel J, Buffa J, Li X, Wang Z, et al.
Cardiovasc Res
. 2021 Aug;
118(10):2367-2384.
PMID: 34352109
Aims: Gut microbiota and their generated metabolites impact the host vascular phenotype. The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with adverse clinical thromboembolic events, and enhances platelet responsiveness...
10.
Ferreira-Gomes M, Kruglov A, Durek P, Heinrich F, Tizian C, Heinz G, et al.
Nat Commun
. 2021 Mar;
12(1):1961.
PMID: 33785765
The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of...