Pawel Durek
Overview
Explore the profile of Pawel Durek including associated specialties, affiliations and a list of published articles.
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73
Citations
2586
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Recent Articles
1.
Goetzke C, Massoud M, Frischbutter S, Guerra G, Ferreira-Gomes M, Heinrich F, et al.
Nature
. 2025 Mar;
PMID: 40074901
In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C...
2.
Troch K, Jakob M, Forster P, Jarick K, Schreiber J, Preusser A, et al.
Nat Commun
. 2024 Dec;
15(1):10566.
PMID: 39632879
Tissue-resident immune cells, such as innate lymphoid cells, mediate protective or detrimental immune responses at barrier surfaces. Upon activation by stromal or epithelial cell-derived alarmins, group 2 innate lymphoid cells...
3.
Wendering D, Amini L, Schlickeiser S, Farrera-Sal M, Schulenberg S, Peter L, et al.
Sci Adv
. 2024 Sep;
10(36):eadn3470.
PMID: 39231218
Regulatory T cells (T cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity and function...
4.
Biniaris-Georgallis S, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, et al.
Nature
. 2024 Aug;
634(8035):952-960.
PMID: 39137897
In systemic lupus erythematosus, loss of immune tolerance, autoantibody production and immune complex deposition are required but not sufficient for organ damage. How inflammatory signals are initiated and amplified in...
5.
Ferreira-Gomes M, Chen Y, Durek P, Rincon-Arevalo H, Heinrich F, Bauer L, et al.
Nat Commun
. 2024 May;
15(1):4182.
PMID: 38755157
Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their...
6.
Wolf C, Lim E, Mokhtari M, Kind B, Odainic A, Lara-Villacanas E, et al.
Sci Immunol
. 2024 Jan;
9(92):eadi9769.
PMID: 38207055
UNC93B1 is critical for trafficking and function of nucleic acid-sensing Toll-like receptors (TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive TLR7 signaling induced by recognition...
7.
Brunner T, Serve S, Marx A, Fadejeva J, Saikali P, Dzamukova M, et al.
Nat Immunol
. 2024 Jan;
25(2):256-267.
PMID: 38172258
The pleiotropic alarmin interleukin-33 (IL-33) drives type 1, type 2 and regulatory T-cell responses via its receptor ST2. Subset-specific differences in ST2 expression intensity and dynamics suggest that transcriptional regulation...
8.
Jani P, Petkau G, Kawano Y, Klemm U, Guerra G, Heinz G, et al.
PLoS Biol
. 2023 Nov;
21(11):e3002015.
PMID: 37983263
Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM...
9.
Bondareva M, Budzinski L, Durek P, Witkowski M, Angermair S, Ninnemann J, et al.
Cell Host Microbe
. 2023 Nov;
31(11):1866-1881.e10.
PMID: 37944493
The commensal microflora provides a repertoire of antigens that illicit mucosal antibodies. In some cases, these antibodies can cross-react with host proteins, inducing autoimmunity, or with other microbial antigens. We...
10.
Shen P, Serve S, Wu P, Liu X, Dai Y, Duran-Hernandez N, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2207993120.
PMID: 37428931
Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age and joint trauma are prominently associated with OA occurrence, the trigger and signaling pathways propagating their...