Validation of Biomarkers of Aging

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2024 Feb 15

PMID 38355974

Authors

Mahdi Moqri

Chiara Herzog

Jesse R Poganik

Kejun Ying

Jamie N Justice

Daniel W Belsky

Albert T Higgins-Chen

Brian H Chen

Alan A Cohen

Georg Fuellen

Sara Hagg

Riccardo E Marioni

Martin Widschwendter

Kristen Fortney

Peter O Fedichev

Alex Zhavoronkov

Nir Barzilai

Jessica Lasky-Su

Douglas P Kiel

Brian K Kennedy

Steven Cummings

P Eline Slagboom

Eric Verdin

Andrea B Maier

Vittorio Sebastiano

Michael P Snyder

Vadim N Gladyshev

Steve Horvath

Luigi Ferrucci

Affiliations

Soon will be listed here.

Abstract

The search for biomarkers that quantify biological aging (particularly 'omic'-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. Here, we review current efforts to evaluate the predictive validity of omic biomarkers of aging in population studies, discuss challenges in comparability and generalizability and provide recommendations to facilitate future validation of biomarkers of aging. Finally, we discuss how systematic validation can accelerate clinical translation of biomarkers of aging and their use in gerotherapeutic clinical trials.

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