Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Oct 27

PMID 36291164

Authors

Jiancheng Yang

Jiawen Wu

Zengfeng Guo

Gejing Zhang

Hao Zhang

Affiliations

Soon will be listed here.

Abstract

Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling.

Citing Articles

Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.

Zhang M, Mi M, Hu Z, Li L, Chen Z, Gao X Drug Des Devel Ther. 2024; 18:3765-3790.

PMID: 39219693 PMC: 11363944. DOI: 10.2147/DDDT.S473007.

Distinct mechanisms of iron and zinc metal ions on osteo-immunomodulation of silicocarnotite bioceramics.

Deng F, Han X, Ji Y, Jin Y, Shao Y, Zhang J Mater Today Bio. 2024; 26:101086.

PMID: 38765245 PMC: 11098954. DOI: 10.1016/j.mtbio.2024.101086.

Novel FeO Nanoparticles with Bioactive Glass-Naproxen Coating: Synthesis, Characterization, and In Vitro Evaluation of Bioactivity.

Valverde T, Dos Santos V, Viana P, Costa G, de Goes A, Sousa L Int J Mol Sci. 2024; 25(8).

PMID: 38673856 PMC: 11049812. DOI: 10.3390/ijms25084270.

Bone Targeting Nanoparticles for the Treatment of Osteoporosis.

Wen C, Xu X, Zhang Y, Xia J, Liang Y, Xu L Int J Nanomedicine. 2024; 19:1363-1383.

PMID: 38371454 PMC: 10871045. DOI: 10.2147/IJN.S444347.

Three-Dimensional Modeling with Osteoblast-like Cells under External Magnetic Field Conditions Using Magnetic Nano-Ferrite Particles for the Development of Cell-Derived Artificial Bone.

Ma C, Izumiya M, Nobuoka H, Ueno R, Mimura M, Ueda K Nanomaterials (Basel). 2024; 14(3).

PMID: 38334522 PMC: 10857141. DOI: 10.3390/nano14030251.

References

Yuan Z, Memarzadeh K, Stephen A, Allaker R, Brown R, Huang J . Development of a 3D Collagen Model for the In Vitro Evaluation of Magnetic-assisted Osteogenesis. Sci Rep. 2018; 8(1):16270. PMC: 6214996. DOI: 10.1038/s41598-018-33455-2. View

Shin J, Swift J, Ivanovska I, Spinler K, Buxboim A, Discher D . Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation. 2013; 86(3):77-86. PMC: 3964600. DOI: 10.1016/j.diff.2013.05.001. View

Fan J, Tan Y, Jie L, Wu X, Yu R, Zhang M . Biological activity and magnetic resonance imaging of superparamagnetic iron oxide nanoparticles-labeled adipose-derived stem cells. Stem Cell Res Ther. 2013; 4(2):44. PMC: 3706947. DOI: 10.1186/scrt191. View

Xiao H, Wang L, Yu B . Superparamagnetic iron oxide promotes osteogenic differentiation of rat adipose-derived stem cells. Int J Clin Exp Med. 2015; 8(1):698-705. PMC: 4358501. View

Gokduman K, Bestepe F, Li L, Yarmush M, Usta O . Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes. Nanomedicine (Lond). 2018; 13(11):1267-1284. PMC: 6219434. DOI: 10.2217/nnm-2017-0387. View

Dadfar S, Roemhild K, Drude N, von Stillfried S, Knuchel R, Kiessling F . Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications. Adv Drug Deliv Rev. 2019; 138:302-325. PMC: 7115878. DOI: 10.1016/j.addr.2019.01.005. View

Meng J, Xiao B, Zhang Y, Liu J, Xue H, Lei J . Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo. Sci Rep. 2013; 3:2655. PMC: 3772377. DOI: 10.1038/srep02655. View

Sun J, Liu X, Huang J, Song L, Chen Z, Liu H . Magnetic assembly-mediated enhancement of differentiation of mouse bone marrow cells cultured on magnetic colloidal assemblies. Sci Rep. 2014; 4:5125. PMC: 4038806. DOI: 10.1038/srep05125. View

Tschulik K, Compton R . Nanoparticle impacts reveal magnetic field induced agglomeration and reduced dissolution rates. Phys Chem Chem Phys. 2014; 16(27):13909-13. DOI: 10.1039/c4cp01618a. View

10.

Liao W, Lu J, Wang Q, Yan S, Li Y, Zhang Y . Osteogenesis of Iron Oxide Nanoparticles-Labeled Human Precartilaginous Stem Cells in Interpenetrating Network Printable Hydrogel. Front Bioeng Biotechnol. 2022; 10:872149. PMC: 9099245. DOI: 10.3389/fbioe.2022.872149. View

11.

Li Y, Ye D, Li M, Ma M, Gu N . Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration. Chemphyschem. 2018; 19(16):1965-1979. DOI: 10.1002/cphc.201701294. View

12.

Marycz K, Sobierajska P, Roecken M, Kornicka-Garbowska K, Kepska M, Idczak R . Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action. J Nanobiotechnology. 2020; 18(1):33. PMC: 7027282. DOI: 10.1186/s12951-020-00590-w. View

13.

Huang Y, Hsu J, Koo H, Cormode D . Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle. Theranostics. 2022; 12(2):796-816. PMC: 8692919. DOI: 10.7150/thno.67375. View

14.

Tran N, Webster T . Increased osteoblast functions in the presence of hydroxyapatite-coated iron oxide nanoparticles. Acta Biomater. 2010; 7(3):1298-306. DOI: 10.1016/j.actbio.2010.10.004. View

15.

Nowogrodzki J . The world's strongest MRI machines are pushing human imaging to new limits. Nature. 2018; 563(7729):24-26. DOI: 10.1038/d41586-018-07182-7. View

16.

Blumler P . Magnetic Guiding with Permanent Magnets: Concept, Realization and Applications to Nanoparticles and Cells. Cells. 2021; 10(10). PMC: 8535073. DOI: 10.3390/cells10102708. View

17.

Li G, Zhang L, Ning K, Yang B, Acosta F, Shang P . Osteocytic Connexin43 Channels Regulate Bone-Muscle Crosstalk. Cells. 2021; 10(2). PMC: 7911162. DOI: 10.3390/cells10020237. View

18.

Yang J, Zhang J, Ding C, Dong D, Shang P . Regulation of Osteoblast Differentiation and Iron Content in MC3T3-E1 Cells by Static Magnetic Field with Different Intensities. Biol Trace Elem Res. 2017; 184(1):214-225. PMC: 5992240. DOI: 10.1007/s12011-017-1161-5. View

19.

Tran N, Webster T . Understanding magnetic nanoparticle osteoblast receptor-mediated endocytosis using experiments and modeling. Nanotechnology. 2013; 24(18):185102. DOI: 10.1088/0957-4484/24/18/185102. View

20.

Wu M, Chen G, Li Y . TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res. 2016; 4:16009. PMC: 4985055. DOI: 10.1038/boneres.2016.9. View