» Articles » PMID: 23790394

Mechanobiology of Bone Marrow Stem Cells: from Myosin-II Forces to Compliance of Matrix and Nucleus in Cell Forms and Fates

Overview
Journal Differentiation
Publisher Elsevier
Date 2013 Jun 25
PMID 23790394
Citations 35
Authors
Affiliations
Soon will be listed here.
Abstract

Adult stem cells and progenitors are of great interest for their clinical application as well as their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is a niche for at least two types of stem cells, and the prototype is the hematopoietic stem cell/progenitors (HSC/Ps), which have saved many thousands of patients for several decades now. In bone marrow, HSC/Ps interact functionally with marrow stromal cells that are often referred to as mesenchymal stem cells (MSCs) or derivatives thereof. Myosin and matrix elasticity greatly affect MSC function, and these mechanobiological factors are now being explored with HSC/Ps both in vitro and in vivo. Also emerging is a role for the nucleus as a mechanically sensitive organelle that is semi-permeable to transcription factors which are modified for nuclear entry by cytoplasmic mechanobiological pathways. Since therapies envisioned with induced pluripotent stem cells and embryonic stem cells generally involve in vitro commitment to an adult stem cell or progenitor, a very deep understanding of stem cell mechanobiology is essential to progress with these multi-potent cells.

Citing Articles

The role of RAP2 in regulation of cell volume on bone marrow mesenchymal stem cell fate determination.

Zhou Y, Guo Y, Zhang M, Quan S, Li J J Mol Histol. 2025; 56(2):79.

PMID: 39903386 DOI: 10.1007/s10735-025-10362-1.


Mechanobiology and Primary Cilium in the Pathophysiology of Bone Marrow Myeloproliferative Diseases.

Tiberio F, Coda A, Tosi D, Luzi D, Polito L, Liso A Int J Mol Sci. 2024; 25(16).

PMID: 39201546 PMC: 11354938. DOI: 10.3390/ijms25168860.


Intravital Microscopy to Study the Effect of Matrix Metalloproteinase Inhibition on Acute Myeloid Leukemia Cell Migration in the Bone Marrow.

Tissot F, Gonzalez-Anton S, Lo Celso C Methods Mol Biol. 2023; 2747:211-227.

PMID: 38038943 DOI: 10.1007/978-1-0716-3589-6_17.


Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling.

Yang J, Wu J, Guo Z, Zhang G, Zhang H Cells. 2022; 11(20).

PMID: 36291164 PMC: 9600888. DOI: 10.3390/cells11203298.


Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex.

Chen J, Song D, Xu Y, Wu L, Tang L, Su Y Front Pharmacol. 2022; 13:896108.

PMID: 36110547 PMC: 9468713. DOI: 10.3389/fphar.2022.896108.


References
1.
Wang F, Kovacs M, Hu A, Limouze J, Harvey E, Sellers J . Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. J Biol Chem. 2003; 278(30):27439-48. DOI: 10.1074/jbc.M302510200. View

2.
Seki M . Hematopoietic colony formation in a macrophage layer provided by intraperitoneal insertion of cellulose acetate membrane. Transplantation. 1973; 16(6):544-9. DOI: 10.1097/00007890-197312000-00002. View

3.
Brown A, Hategan A, Safer D, Goldman Y, Discher D . Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J. 2009; 96(5):1952-60. PMC: 2717282. DOI: 10.1016/j.bpj.2008.11.032. View

4.
Zhang Y, Conti M, Malide D, Dong F, Wang A, Shmist Y . Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2011; 119(1):238-50. PMC: 3251230. DOI: 10.1182/blood-2011-06-358853. View

5.
Tsai R, Discher D . Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol. 2008; 180(5):989-1003. PMC: 2265407. DOI: 10.1083/jcb.200708043. View