The Effect of Sauce, As a Functional Food, on Cardiometabolic Risk Factors, Oxidative Stress Biomarkers, Glycemic Profile, and Liver Enzymes in Nonalcoholic Fatty Liver Disease Patients: A Randomized Double-blinded Clinical Trial

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2022 Feb 14

PMID 35154670

Authors

Seyed Mohammad Mazloomi

Mohammad Samadi

Hajar Davarpanah

Siavash Babajafari

Cain C T Clark

Zohreh Ghaemfar

Mojtaba Rezaiyan

Abdolhamid Mosallanezhad

Maryam Shafiee

Hosein Rostami

Affiliations

Soon will be listed here.

Abstract

Objective: This study sought to investigate the effect of on cardiometabolic risk factors, oxidative stress biomarkers, glycemic profile, and liver enzymes in nonalcoholic fatty liver disease (NAFLD) patients.

Methods: This randomized, double-blind clinical trial was performed on 46 NAFLD patients. Subjects were allocated to consume either sauce or placebo, each 20 g/day for 8 weeks. Fatty liver grade, liver enzymes, anthropometric parameters, blood pressure, and serum lipids, glucose, insulin, malondialdehyde, and antioxidant capacity were assessed pre- and postintervention.

Results: Fatty liver grade was significantly different between the two groups. A significant change for ALT (alanine aminotransferase) and AST (aspartate aminotransferase) was seen between the two groups ( = .03 and .02, respectively), while ALP (alkaline phosphatase) serum levels were not significantly different within or between groups. Pertaining to glycemic profile, all variables, except HOMA-IR, were not significantly different within or between groups. Finally, statistically significant changes were seen in both MDA (malondialdehyde) and TAC (total antioxidant capacity) among the groups ( = .04 and <.001, respectively).

Conclusions: may improve fatty liver grade by modifying liver enzymes, oxidative stress, and some lipid profiles; however, there was effect of on anthropometric characteristics and blood pressure.

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