Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Feb 3

PMID 35111760

Authors

Sajad Najafi

Soudeh Ghafouri-Fard

Bashdar Mahmud Hussen

Hazha Hadayat Jamal

Mohammad Taheri

Mohammad Hallajnejad

Affiliations

Soon will be listed here.

Abstract

Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts characterized with more than 200 nucleotides of length. Unlike their names, some short open reading frames are recognized for them encoding small proteins. LncRNAs are found to play regulatory roles in essential cellular processes such as cell growth and apoptosis. Therefore, an increasing number of lncRNAs are identified with dysregulation in a wide variety of human cancers. SNHG7 is an lncRNA with upregulation in cancer cells and tissues. It is frequently reported with potency of promoting malignant cell behaviors and . Like oncogenic/tumor suppressor lncRNAs, SNHG7 is found to exert its tumorigenic functions through interaction with other biological substances. These include sponging target miRNAs (various numbers are identified), regulation of several signaling pathways, transcription factors, and effector proteins. Importantly, clinical studies demonstrate association between high SNHG7 expression and clinicopathological features in cancerous patients, worse prognosis, and enhanced chemoresistance. In this review, we summarize recent studies in three eras of cell, animal, and human experiments to bold the prognostic, diagnostic, and therapeutic potentials.

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References

Sayad A, Najafi S, Kashi A, Hosseini S, Akrami S, Taheri M . Circular RNAs in renal cell carcinoma: Functions in tumorigenesis and diagnostic and prognostic potentials. Pathol Res Pract. 2021; 229:153720. DOI: 10.1016/j.prp.2021.153720. View

Zhong X, Long Z, Wu S, Xiao M, Hu W . LncRNA-SNHG7 regulates proliferation, apoptosis and invasion of bladder cancer cells assurance guidelines. J BUON. 2018; 23(3):776-781. View

Shen A, Ma J, Hu X, Cui X . High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma. Oncol Lett. 2020; 19(6):3959-3963. PMC: 7202315. DOI: 10.3892/ol.2020.11490. View

Xu C, Zhou J, Wang Y, Wang A, Su L, Liu S . Inhibition of malignant human bladder cancer phenotypes through the down-regulation of the long non-coding RNA SNHG7. J Cancer. 2019; 10(2):539-546. PMC: 6360294. DOI: 10.7150/jca.25507. View

Li Y, Zeng C, Hu J, Pan Y, Shan Y, Liu B . Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. J Hematol Oncol. 2018; 11(1):89. PMC: 6029165. DOI: 10.1186/s13045-018-0632-2. View

Deng Y, Cheng L, Lv Z, Zhu H, Meng X . lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR-138-5p to regulate EZH2 expression. Oncol Lett. 2021; 22(1):565. PMC: 8185700. DOI: 10.3892/ol.2021.12826. View

Sarropoulos I, Marin R, Cardoso-Moreira M, Kaessmann H . Developmental dynamics of lncRNAs across mammalian organs and species. Nature. 2019; 571(7766):510-514. PMC: 6660317. DOI: 10.1038/s41586-019-1341-x. View

Chen Z, He M, Chen J, Li C, Zhang Q . Long non-coding RNA SNHG7 inhibits NLRP3-dependent pyroptosis by targeting the miR-34a/SIRT1 axis in liver cancer. Oncol Lett. 2020; 20(1):893-901. PMC: 7285900. DOI: 10.3892/ol.2020.11635. View

Hartford C, Lal A . When Long Noncoding Becomes Protein Coding. Mol Cell Biol. 2020; 40(6). PMC: 7048269. DOI: 10.1128/MCB.00528-19. View

10.

Wang Y, Bao D, Wan L, Zhang C, Hui S, Guo H . Long non-coding RNA small nucleolar RNA host gene 7 facilitates the proliferation, migration, and invasion of esophageal cancer cells by regulating microRNA-625. J Gastrointest Oncol. 2021; 12(2):423-432. PMC: 8107616. DOI: 10.21037/jgo-21-147. View

11.

Chen L, Zhu J, Zhang L . Long non-coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer. Oncol Lett. 2019; 18(5):4726-4734. PMC: 6781492. DOI: 10.3892/ol.2019.10782. View

12.

Al-Tobasei R, Paneru B, Salem M . Genome-Wide Discovery of Long Non-Coding RNAs in Rainbow Trout. PLoS One. 2016; 11(2):e0148940. PMC: 4764514. DOI: 10.1371/journal.pone.0148940. View

13.

Jensen E . Real-time reverse transcription polymerase chain reaction to measure mRNA: use, limitations, and presentation of results. Anat Rec (Hoboken). 2011; 295(1):1-3. DOI: 10.1002/ar.21487. View

14.

Hu Y, Wang L, Li Z, Wan Z, Shao M, Wu S . Potential Prognostic and Diagnostic Values of CDC6, CDC45, ORC6 and SNHG7 in Colorectal Cancer. Onco Targets Ther. 2020; 12:11609-11621. PMC: 6942537. DOI: 10.2147/OTT.S231941. View

15.

Elgar G, Vavouri T . Tuning in to the signals: noncoding sequence conservation in vertebrate genomes. Trends Genet. 2008; 24(7):344-52. DOI: 10.1016/j.tig.2008.04.005. View

16.

Cheng D, Fan J, Ma Y, Zhou Y, Qin K, Shi M . LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p. Cell Biosci. 2019; 9:28. PMC: 6431029. DOI: 10.1186/s13578-019-0290-2. View

17.

Yue X, Dong C, Ye Z, Zhu L, Zhang X, Wang X . LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression. Metab Brain Dis. 2020; 36(1):123-132. DOI: 10.1007/s11011-020-00611-5. View

18.

Li Z, Yu N, Deng Q, Zhang Y, Hu Y, Liu G . LncRNA SNHG7 Mediates the Chemoresistance and Stemness of Breast Cancer by Sponging miR-34a. Front Oncol. 2020; 10:592757. PMC: 7732589. DOI: 10.3389/fonc.2020.592757. View

19.

Najafi S, Tan S, Raee P, Rahmati Y, Asemani Y, Lee E . Gene regulation by antisense transcription: A focus on neurological and cancer diseases. Biomed Pharmacother. 2021; 145:112265. DOI: 10.1016/j.biopha.2021.112265. View

20.

Zhang X, Wang W, Zhu W, Dong J, Cheng Y, Yin Z . Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels. Int J Mol Sci. 2019; 20(22). PMC: 6888083. DOI: 10.3390/ijms20225573. View