» Articles » PMID: 36419933

Mechanistic Studies of MALAT1 in Respiratory Diseases

Overview
Specialty Biology
Date 2022 Nov 24
PMID 36419933
Authors
Affiliations
Soon will be listed here.
Abstract

The incidence of respiratory diseases and the respiratory disease mortality rate have increased in recent years. Recent studies have shown that long non-coding RNA (lncRNA) MALAT1 is involved in various respiratory diseases. In vascular endothelial and cancer cells, MALAT1 expression triggers various changes such as proinflammatory cytokine expression, cancer cell proliferation and metastasis, and increased endothelial cell permeability. In this review, we performed a relative concentration index (RCI) analysis of the lncRNA database to assess differences in MALAT1 expression in different cell lines and at different locations in the same cell, and summarize the molecular mechanisms of MALAT1 in the pathophysiology of respiratory diseases and its potential therapeutic application in these conditions. MALAT1 plays an important regulatory role in lncRNA with a wide range of effects in respiratory diseases. The available evidence shows that MALAT1 plays an important role in the regulation of multiple respiratory diseases. MALAT1 is an important regulatory biomarker for respiratory disease. Targeting the regulation MALAT1 could have important applications for the future treatment of respiratory diseases.

Citing Articles

MALAT1 predicts the prognosis of severe community-acquired pneumonia in pediatric patients.

Yang M, Xuan A, Liu Q, Zhu G BMC Pulm Med. 2024; 24(1):361.

PMID: 39061025 PMC: 11282807. DOI: 10.1186/s12890-024-03157-9.


scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis.

Zhang W, Huang H, Liu X, Zhang L, Li L, Ding Y Invest Ophthalmol Vis Sci. 2024; 65(3):38.

PMID: 38551583 PMC: 10981439. DOI: 10.1167/iovs.65.3.38.


The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease.

Curran C, Kopp J J Transl Med. 2023; 21(1):706.

PMID: 37814337 PMC: 10563221. DOI: 10.1186/s12967-023-04584-8.


Emerging role of long non-coding RNA MALAT1 related signaling pathways in the pathogenesis of lung disease.

Liu J, Ali M, Mao Y Front Cell Dev Biol. 2023; 11:1149499.

PMID: 37250901 PMC: 10213921. DOI: 10.3389/fcell.2023.1149499.


LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer.

Hao L, Wu W, Xu Y, Chen Y, Meng C, Yun J Molecules. 2023; 28(5).

PMID: 36903369 PMC: 10004581. DOI: 10.3390/molecules28052126.


References
1.
Collins J, Tibboel D, De Kleer I, Reiss I, Rottier R . The Future of Bronchopulmonary Dysplasia: Emerging Pathophysiological Concepts and Potential New Avenues of Treatment. Front Med (Lausanne). 2017; 4:61. PMC: 5439211. DOI: 10.3389/fmed.2017.00061. View

2.
Sun L, Xu A, Li M, Xia X, Li P, Han R . Effect of Methylation Status of lncRNA-MALAT1 and MicroRNA-146a on Pulmonary Function and Expression Level of COX2 in Patients With Chronic Obstructive Pulmonary Disease. Front Cell Dev Biol. 2021; 9:667624. PMC: 8479795. DOI: 10.3389/fcell.2021.667624. View

3.
Tano K, Mizuno R, Okada T, Rakwal R, Shibato J, Masuo Y . MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 2010; 584(22):4575-80. DOI: 10.1016/j.febslet.2010.10.008. View

4.
Dai L, Zhang G, Cheng Z, Wang X, Jia L, Jing X . Knockdown of LncRNA MALAT1 contributes to the suppression of inflammatory responses by up-regulating miR-146a in LPS-induced acute lung injury. Connect Tissue Res. 2018; 59(6):581-592. DOI: 10.1080/03008207.2018.1439480. View

5.
Tang Y, Xiao G, Chen Y, Deng Y . LncRNA MALAT1 promotes migration and invasion of non-small-cell lung cancer by targeting miR-206 and activating Akt/mTOR signaling. Anticancer Drugs. 2018; 29(8):725-735. DOI: 10.1097/CAD.0000000000000650. View