The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Mar 17

PMID 35296022

Authors

Soudeh Ghafouri-Fard

Sajad Najafi

Bashdar Mahmud Hussen

Abbas Basiri

Hazha Jamal Hidayat

Mohammad Taheri

Fariborz Rashnoo

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder cancer. Several circRNAs such as circ_0058063, hsa-circRNA-403658, circPDSS1, circCASC15, circRNA-MYLK, and circRNA_103809 have been upregulated in bladder cancer samples. On the other hand, hsa_circ_0137606, BCRC-3, circFUT8, hsa_circ_001598, circSLC8A1, hsa_circ_0077837, hsa_circ_0004826, and circACVR2A are among downregulated circRNAs in bladder cancer. Numerous circRNAs have diagnostic or prognostic value in bladder cancer. In this review, we aim to outline the latest findings about the role of circRNAs in bladder cancer and introduce circRNAs for further investigations as therapeutic targets.

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