Anatomical Structures, Cell Types and Biomarkers of the Human Reference Atlas

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2021 Nov 9

PMID 34750582

Citations 51

Authors

Katy Borner

Sarah A Teichmann

Ellen M Quardokus

James C Gee

Kristen Browne

David Osumi-Sutherland

Bruce W Herr 2nd

Andreas Bueckle

Hrishikesh Paul

Muzlifah Haniffa

Laura Jardine

Amy Bernard

Song-Lin Ding

Jeremy A Miller

Shin Lin

Marc K Halushka

Avinash Boppana

Teri A Longacre

John Hickey

Yiing Lin

M Todd Valerius

Yongqun He

Gloria Pryhuber

Xin Sun

Marda Jorgensen

Andrea J Radtke

Clive Wasserfall

Fiona Ginty

Jonhan Ho

Joel Sunshine

Rebecca T Beuschel

Maigan Brusko

Sujin Lee

Rajeev Malhotra

Sanjay Jain

Griffin Weber

Affiliations

Soon will be listed here.

Abstract

The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

Citing Articles

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.

Borner K, Blood P, Silverstein J, Ruffalo M, Satija R, Teichmann S Nat Methods. 2025; .

PMID: 40082611 DOI: 10.1038/s41592-024-02563-5.

Spatial top-down proteomics for the functional characterization of human kidney.

Zemaitis K, Fulcher J, Kumar R, Degnan D, Lewis L, Liao Y Clin Proteomics. 2025; 22(1):9.

PMID: 40045235 PMC: 11881370. DOI: 10.1186/s12014-025-09531-x.

Functional tissue units in the Human Reference Atlas.

Bidanta S, Borner K, Herr Ii B, Quardokus E, Nagy M, Gustilo K Nat Commun. 2025; 16(1):1526.

PMID: 39934102 PMC: 11814273. DOI: 10.1038/s41467-024-54591-6.

Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph for Linked Open Data.

Bueckle A, Herr 2nd B, Herr B, Hardi J, Quardokus E, Musen M bioRxiv. 2025; .

PMID: 39764040 PMC: 11703146. DOI: 10.1101/2024.12.22.630006.

A general strategy for generating expert-guided, simplified views of ontologies.

Caron A, Puig-Barbe A, Quardokus E, Balhoff J, Belfiore J, Chipampe N bioRxiv. 2025; .

PMID: 39763856 PMC: 11702530. DOI: 10.1101/2024.12.13.628309.

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