M Todd Valerius
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Explore the profile of M Todd Valerius including associated specialties, affiliations and a list of published articles.
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45
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4905
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Recent Articles
1.
He Y, Barisoni L, Rosenberg A, Robinson P, Diehl A, Chen Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38617362
Many resources are now generating, processing, storing, or providing kidney-related molecular, pathological, and clinical data. Reference ontologies offer an opportunity to support knowledge and data organization and integration. The Kidney...
2.
Galichon P, Lannoy M, Li L, Serre J, Vandermeersch S, Legouis D, et al.
Am J Physiol Renal Physiol
. 2024 Jan;
326(3):F326-F337.
PMID: 38205542
Acute kidney injury activates both proliferative and antiproliferative pathways, the consequences of which are not fully elucidated. If an initial proliferation of the renal epithelium is necessary for the successful...
3.
Hiratsuka K, Miyoshi T, Kroll K, Gupta N, Valerius M, Ferrante T, et al.
Sci Adv
. 2022 Sep;
8(38):eabq0866.
PMID: 36129975
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully...
4.
Shi M, McCracken K, Patel A, Zhang W, Ester L, Valerius M, et al.
Nat Biotechnol
. 2022 Aug;
41(2):252-261.
PMID: 36038632
Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe highly efficient, serum-free differentiation of...
5.
Hansen J, Sealfon R, Menon R, Eadon M, Lake B, Steck B, et al.
Sci Adv
. 2022 Jun;
8(23):eabn4965.
PMID: 35675394
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference...
6.
Naved B, Bonventre J, Hubbell J, Hukriede N, Humphreys B, Kesselman C, et al.
Kidney Int
. 2022 Mar;
101(5):845-853.
PMID: 35276204
Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial...
7.
Borner K, Teichmann S, Quardokus E, Gee J, Browne K, Osumi-Sutherland D, et al.
Nat Cell Biol
. 2021 Nov;
23(11):1117-1128.
PMID: 34750582
The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members...
8.
Li L, Galichon P, Xiao X, Figueroa-Ramirez A, Tamayo D, Lee J, et al.
EMBO Rep
. 2021 May;
22(6):e51169.
PMID: 34031962
Recent studies demonstrate that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as...
9.
Ong E, Wang L, Schaub J, OToole J, Steck B, Rosenberg A, et al.
Nat Rev Nephrol
. 2020 Sep;
16(11):686-696.
PMID: 32939051
An important need exists to better understand and stratify kidney disease according to its underlying pathophysiology in order to develop more precise and effective therapeutic agents. National collaborative efforts such...
10.
Wilflingseder J, Willi M, Lee H, Olauson H, Jankowski J, Ichimura T, et al.
Nat Commun
. 2020 Jul;
11(1):3383.
PMID: 32636391
The endogenous repair process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and progressive kidney...