Positive Control of D-serine Deaminase Synthesis in Vitro

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1978 Apr 1

PMID 347444

Citations 6

Authors

M C Heincz

N E KELKER

E MCFALL

Affiliations

Soon will be listed here.

Abstract

Efficient constitutive synthesis of D-serine deaminase [D-serine hydro-lyase (deaminating); EC 4.2.1.14] is obtained in vitro by using a slightly modified Zubay system programmed with dsdO6 dsdA+DNA. Synthesis from a dsdO+ dsdA+ template requires active dsdC gene product and 3':5'-cyclic AMP. In vitro synthesis of dsdC product is obtained with a dsdC+ dsdO+ dsdA+ or a dsdCc dsdO+ dsdA+ template; this synthesis is thermosensitive and can be uncoupled from D-serine deaminase synthesis by temperature shift.

Citing Articles

dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073.

Hryckowian A, Baisa G, Schwartz K, Welch R PLoS One. 2015; 10(9):e0138121.

PMID: 26366567 PMC: 4569052. DOI: 10.1371/journal.pone.0138121.

Position effect on expression of dsd genes cloned onto multicopy plasmids.

Carothers A, Heincz M, MCFALL E J Bacteriol. 1980; 142(1):185-90.

PMID: 6989803 PMC: 293926. DOI: 10.1128/jb.142.1.185-190.1980.

Kinetics and regulation of cell-free alkaline phosphatase synthesis.

Pratt C J Bacteriol. 1980; 143(3):1265-74.

PMID: 6157671 PMC: 294493. DOI: 10.1128/jb.143.3.1265-1274.1980.

Effects of structural changes in the dsdA-dsdC intergenic region on D-serine deaminase synthesis.

MCFALL E, Nikam S, Palchaudhuri S J Bacteriol. 1991; 173(3):1161-7.

PMID: 1899415 PMC: 207237. DOI: 10.1128/jb.173.3.1161-1167.1991.

Role of the dsdC activator in regulation of D-serine deaminase synthesis.

Heincz M, MCFALL E J Bacteriol. 1978; 136(1):96-103.

PMID: 213419 PMC: 218636. DOI: 10.1128/jb.136.1.96-103.1978.

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