Liquid Biopsy As a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Oct 23

PMID 34680596

Citations 1

Authors

Elisabeth Perez-Ruiz

Vanesa Gutierrez

Marta Munoz

Javier Oliver

Marta Sanchez

Laura Galvez-Carvajal

Antonio Rueda-Dominguez

Isabel Barragan

Affiliations

Soon will be listed here.

Abstract

Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.

Citing Articles

Circulating biomarkers in oral cancer: Unravelling the mystery.

Prakash N, Pradeep G J Oral Maxillofac Pathol. 2023; 26(3):300-306.

PMID: 36588829 PMC: 9802512. DOI: 10.4103/jomfp.jomfp_338_22.

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