Cell-Free MicroRNAs As Potential Oral Cancer Biomarkers: From Diagnosis to Therapy

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Dec 22

PMID 31861130

Citations 18

Authors

Oscar Rapado-Gonzalez

Rafael Lopez-Lopez

Jose Luis Lopez-Cedrun

Gabriel Triana-Martinez

Laura Muinelo-Romay

Maria Mercedes Suarez-Cunqueiro

Affiliations

Soon will be listed here.

Abstract

Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninvasive biomarkers to improve early detection of this tumor. Liquid biopsy has emerged as a valuable tool in medical oncology which provides new horizons for improving clinical decision making. Notably, cell-free microRNAs (miRNAs), a class of short non-coding RNAs, are emerging as novel noninvasive cancer biomarkers. Here, we provide an overview of the potential clinical application of cell-free miRNAs as diagnostic, prognostic, and therapeutic biomarkers in oral cancer.

Citing Articles

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Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer.

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