Circulating Biomarkers in Oral Cancer: Unravelling the Mystery

Overview

Journal J Oral Maxillofac Pathol

Date 2023 Jan 2

PMID 36588829

Authors

Nilima Prakash

G L Pradeep

Affiliations

Soon will be listed here.

Abstract

Oral squamous cell carcinoma (OSCC) is among the most common malignancies and a leading cause of death in developing countries. Late diagnosis and regional and/or distant metastasis worsen the prognosis of this condition. Despite the advances in diagnostic modalities and management strategies, there is little improvement in the 5-year survival rate. A deeper insight into the molecular events of various tumours has enabled the use of minimally invasive methods for monitoring disease progression, prognostication and treatment monitoring. Although studies in OSCC are preliminary, the use of liquid biopsies has opened new frontiers for the development of biomarkers that can serve as alternatives to conventional biopsies and imaging methods. Circulating biomarkers in blood allow for the real-time monitoring of tumour and therapeutic responses. This review aims to outline the promises and challenges of circulating biomarkers in OSCC with special emphasis on circulating tumour cells, circulating tumor DNA, and exosomes.

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References

Plaks V, Koopman C, Werb Z . Cancer. Circulating tumor cells. Science. 2013; 341(6151):1186-8. PMC: 3842225. DOI: 10.1126/science.1235226. View

Dawson S, Tsui D, Murtaza M, Biggs H, Rueda O, Chin S . Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013; 368(13):1199-209. DOI: 10.1056/NEJMoa1213261. View

Bidard F, Weigelt B, Reis-Filho J . Going with the flow: from circulating tumor cells to DNA. Sci Transl Med. 2013; 5(207):207ps14. DOI: 10.1126/scitranslmed.3006305. View

Haber D, Velculescu V . Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA. Cancer Discov. 2014; 4(6):650-61. PMC: 4433544. DOI: 10.1158/2159-8290.CD-13-1014. View

Park J, Tan H, Datta A, Lai R, Zhang H, Meng W . Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics. 2010; 9(6):1085-99. PMC: 2877972. DOI: 10.1074/mcp.M900381-MCP200. View

Mouliere F, Chandrananda D, Piskorz A, Moore E, Morris J, Ahlborn L . Enhanced detection of circulating tumor DNA by fragment size analysis. Sci Transl Med. 2018; 10(466). PMC: 6483061. DOI: 10.1126/scitranslmed.aat4921. View

Mehes G, Witt A, Kubista E, Ambros P . Circulating breast cancer cells are frequently apoptotic. Am J Pathol. 2001; 159(1):17-20. PMC: 1850424. DOI: 10.1016/S0002-9440(10)61667-7. View

Parikh A, Corcoran R . Monitoring resistance through liquid biopsy. Ann Oncol. 2017; 29(1):8-11. PMC: 6658708. DOI: 10.1093/annonc/mdx650. View

Zhang W, Xia W, Lv Z, Ni C, Xin Y, Yang L . Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?. Cell Physiol Biochem. 2017; 41(2):755-768. DOI: 10.1159/000458736. View

10.

Bronkhorst A, Ungerer V, Holdenrieder S . The emerging role of cell-free DNA as a molecular marker for cancer management. Biomol Detect Quantif. 2019; 17:100087. PMC: 6425120. DOI: 10.1016/j.bdq.2019.100087. View

11.

SLAUGHTER D, SOUTHWICK H, SMEJKAL W . Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953; 6(5):963-8. DOI: 10.1002/1097-0142(195309)6:5<963::aid-cncr2820060515>3.0.co;2-q. View

12.

Wang J, Chang S, Li G, Sun Y . Application of liquid biopsy in precision medicine: opportunities and challenges. Front Med. 2017; 11(4):522-527. DOI: 10.1007/s11684-017-0526-7. View

13.

Cho E, Wendel M, Luttgen M, Yoshioka C, Marrinucci D, Lazar D . Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. 2012; 9(1):016001. PMC: 3387999. DOI: 10.1088/1478-3975/9/1/016001. View

14.

Siravegna G, Marsoni S, Siena S, Bardelli A . Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol. 2017; 14(9):531-548. DOI: 10.1038/nrclinonc.2017.14. View

15.

Hamana K, Uzawa K, Ogawara K, Shiiba M, Bukawa H, Yokoe H . Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma. Br J Cancer. 2005; 92(12):2181-4. PMC: 2361808. DOI: 10.1038/sj.bjc.6602635. View

16.

Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H . Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS One. 2016; 11(7):e0159693. PMC: 4956265. DOI: 10.1371/journal.pone.0159693. View

17.

Lousada-Fernandez F, Rapado-Gonzalez O, Lopez-Cedrun J, Lopez-Lopez R, Muinelo-Romay L, Suarez-Cunqueiro M . Liquid Biopsy in Oral Cancer. Int J Mol Sci. 2018; 19(6). PMC: 6032225. DOI: 10.3390/ijms19061704. View

18.

Gonzalez-Santiago S, Ramon Y Cajal T, Aguirre E, Ales-Martinez J, Andres R, Balmana J . SEOM clinical guidelines in hereditary breast and ovarian cancer (2019). Clin Transl Oncol. 2020; 22(2):193-200. DOI: 10.1007/s12094-019-02262-0. View

19.

Allen J, Saroya B, Kunkel M, Dicker D, Das A, Peters K . Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs. Oncotarget. 2013; 5(7):1753-60. PMC: 4039127. DOI: 10.18632/oncotarget.1524. View

20.

Anitha N, Jimson S, Masthan K, Jacobina J . Circulating tumor cells in oral squamous cell carcinoma-an enigma or reality?. J Pharm Bioallied Sci. 2015; 7(Suppl 1):S173-5. PMC: 4439662. DOI: 10.4103/0975-7406.155893. View