Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Aug 28

PMID 32850402

Citations 15

Authors

Ann Katrin Sauer

Hector Vela

Guillermo Vela

Peter Stark

Eduardo Barrera-Juarez

Andreas M Grabrucker

Affiliations

Soon will be listed here.

Abstract

Research has been consistently showing the role of zinc (Zn) in prostate function. In this article, we review the current literature on the anatomy and main functions of the prostate, highlighting the role of zinc. In particular, we will review the etiology of benign prostate enlargement (BPH), its prevalence in men over 50, the likelihood of BPH becoming prostate cancer (PCa), and explain the relationship of zinc and apoptosis in the prostate cells and the implications for BPH and PCa. We present a model that explains how endogenous factors provoke excretion of zinc or limit zinc absorption, and how exogenous factors like nutrition and drugs regularly used in men over 50 can significantly decrease zinc status and thereby increase the risk of BPH. Finally, we explain how Zn amino acid (AA) complexes may be capable of avoiding antagonists and inhibitors of zinc absorption, thereby increasing the bioavailability of zinc for the necessary biological processes in the prostate.

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References

Wakwe V, Odum E, Amadi C . The impact of plasma zinc status on the severity of prostate cancer disease. Investig Clin Urol. 2019; 60(3):162-168. PMC: 6495034. DOI: 10.4111/icu.2019.60.3.162. View

Cicero A, Allkanjari O, Busetto G, Cai T, Largana G, Magri V . Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer. Arch Ital Urol Androl. 2019; 91(3). DOI: 10.4081/aiua.2019.3.139. View

Zima T, Mestek O, Nemecek K, Bartova V, Fialova J, Tesar V . Trace elements in hemodialysis and continuous ambulatory peritoneal dialysis patients. Blood Purif. 1999; 16(5):253-60. DOI: 10.1159/000014342. View

Eybl V, Koutenska M, Koutensky J, Sykora J, Smolikova V . Influence of triethylenetetramine and D-penicillamine on zinc metabolism in mice. Arch Toxicol Suppl. 1989; 13:370-2. DOI: 10.1007/978-3-642-74117-3_72. View

Mohammad M, Mohommad M, Zhou Z, Cave M, Barve A, McClain C . Zinc and liver disease. Nutr Clin Pract. 2012; 27(1):8-20. PMC: 6027651. DOI: 10.1177/0884533611433534. View

Hambidge K, Miller L, Westcott J, Sheng X, Krebs N . Zinc bioavailability and homeostasis. Am J Clin Nutr. 2010; 91(5):1478S-1483S. PMC: 2854914. DOI: 10.3945/ajcn.2010.28674I. View

Hambidge K . Zinc and diarrhea. Acta Paediatr Suppl. 1992; 381:82-6. DOI: 10.1111/j.1651-2227.1992.tb12377.x. View

Roohani N, Hurrell R, Kelishadi R, Schulin R . Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013; 18(2):144-57. PMC: 3724376. View

Roehrborn C . Benign prostatic hyperplasia: an overview. Rev Urol. 2006; 7 Suppl 9:S3-S14. PMC: 1477638. View

10.

De Nunzio C, Aronson W, Freedland S, Giovannucci E, Parsons J . The correlation between metabolic syndrome and prostatic diseases. Eur Urol. 2011; 61(3):560-70. DOI: 10.1016/j.eururo.2011.11.013. View

11.

Costello L, Franklin R . Zinc is decreased in prostate cancer: an established relationship of prostate cancer!. J Biol Inorg Chem. 2010; 16(1):3-8. PMC: 3735606. DOI: 10.1007/s00775-010-0736-9. View

12.

McConnell J . The pathophysiology of benign prostatic hyperplasia. J Androl. 1991; 12(6):356-63. View

13.

Amory J, Wang C, Swerdloff R, Anawalt B, Matsumoto A, Bremner W . The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab. 2007; 92(5):1659-65. DOI: 10.1210/jc.2006-2203. View

14.

Miah S, Catto J . BPH and prostate cancer risk. Indian J Urol. 2014; 30(2):214-8. PMC: 3989826. DOI: 10.4103/0970-1591.126909. View

15.

Aaron L, Franco O, Hayward S . Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia. Urol Clin North Am. 2016; 43(3):279-88. PMC: 4968575. DOI: 10.1016/j.ucl.2016.04.012. View

16.

Arts J, Bade S, Badrinas M, Ball N, Hindle S . Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant?. Regul Toxicol Pharmacol. 2018; 97:197-208. DOI: 10.1016/j.yrtph.2018.06.019. View

17.

Tiscione D, Gallelli L, Tamanini I, Luciani L, Verze P, Palmieri A . Daidzein plus isolase associated with zinc improves clinical symptoms and quality of life in patients with LUTS due to benign prostatic hyperplasia: Results from a phase I-II study. Arch Ital Urol Androl. 2017; 89(1):12-16. DOI: 10.4081/aiua.2017.1.12. View

18.

Crofton R, Aggett P, Gvozdanovic S, Gvozdanovic D, Mowat N, Brunt P . Zinc metabolism in celiac disease. Am J Clin Nutr. 1990; 52(2):379-82. DOI: 10.1093/ajcn/52.2.379. View

19.

Costello L, Franklin R . Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity. Expert Rev Anticancer Ther. 2011; 12(1):121-8. PMC: 3291177. DOI: 10.1586/era.11.190. View

20.

Sundaram A, Koutkia P, Apovian C . Nutritional management of short bowel syndrome in adults. J Clin Gastroenterol. 2002; 34(3):207-20. DOI: 10.1097/00004836-200203000-00003. View