Zinc in Prostate Health and Disease: A Mini Review

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Dec 23

PMID 36551962

Authors

Nishi Karunasinghe

Affiliations

Soon will be listed here.

Abstract

-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. -General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. -The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. -The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.

Citing Articles

Comparative study of trace metal concentration in the diagnosis of category III prostatitis.

Lin Z, Li M, Zhang M, Gong Y, Gan X, Liang W BMC Urol. 2024; 24(1):259.

PMID: 39604918 PMC: 11600811. DOI: 10.1186/s12894-024-01656-9.

Dextran-Graft-Polyacrylamide/Zinc Oxide Nanoparticles Inhibit of Cancer Cells in vitro and in vivo.

Virych P, Virych P, Prokopiuk V, Onishchenko A, Ischenko M, Doroschuk V Int J Nanomedicine. 2024; 19:11719-11743.

PMID: 39553459 PMC: 11566607. DOI: 10.2147/IJN.S485106.

Emerging Perspectives in Zinc Transporter Research in Prostate Cancer: An Updated Review.

Acevedo S, Segovia M, De la Fuente-Ortega E Nutrients. 2024; 16(13).

PMID: 38999774 PMC: 11243615. DOI: 10.3390/nu16132026.

Zinc Finger Proteins in the War on Gastric Cancer: Molecular Mechanism and Clinical Potential.

Liu S, Liu X, Lin X, Chen H Cells. 2023; 12(9).

PMID: 37174714 PMC: 10177130. DOI: 10.3390/cells12091314.

References

Chilvers D, Dawson J, Bahreyni-Toosi M, Hodgkinson A . Identification and determination of copper--and zinc--protein complexes in blood plasma after chromatographic separation on DEAE-Sepharose CL-6B. Analyst. 1984; 109(7):871-6. DOI: 10.1039/an9840900871. View

Kroncke K . Zinc finger proteins as molecular targets for nitric oxide-mediated gene regulation. Antioxid Redox Signal. 2001; 3(4):565-75. DOI: 10.1089/15230860152542934. View

Iguchi K, Otsuka T, Usui S, Ishii K, Onishi T, Sugimura Y . Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. J Androl. 2003; 25(1):154-61. DOI: 10.1002/j.1939-4640.2004.tb02771.x. View

Inoue K, Matsuda K, Itoh M, Kawaguchi H, Tomoike H, Aoyagi T . Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Hum Mol Genet. 2002; 11(15):1775-84. DOI: 10.1093/hmg/11.15.1775. View

Kirschke C, Huang L . Expression of the ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. J Mol Histol. 2008; 39(4):359-70. DOI: 10.1007/s10735-008-9174-1. View

Taylor K, Hiscox S, Nicholson R, Hogstrand C, Kille P . Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Sci Signal. 2012; 5(210):ra11. PMC: 3428905. DOI: 10.1126/scisignal.2002585. View

Franklin R, Feng P, Milon B, Desouki M, Singh K, Kajdacsy-Balla A . hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer. 2005; 4:32. PMC: 1243239. DOI: 10.1186/1476-4598-4-32. View

Loffek S, Schilling O, Franzke C . Series "matrix metalloproteinases in lung health and disease": Biological role of matrix metalloproteinases: a critical balance. Eur Respir J. 2010; 38(1):191-208. DOI: 10.1183/09031936.00146510. View

Yamanaka Y, Matsugano S, Yoshikawa Y, Orino K . Binding Analysis of Human Immunoglobulin G as a Zinc-Binding Protein. Antibodies (Basel). 2019; 5(2). PMC: 6698836. DOI: 10.3390/antib5020013. View

10.

Liang W, Chen W, Wei J, Yao H, Shi J, Hou X . Zinc finger C3H1-type containing serves as a novel prognostic biomarker in human pan-cancer. Gene. 2022; 820:146251. DOI: 10.1016/j.gene.2022.146251. View

11.

Liuzzi J, Cousins R . Mammalian zinc transporters. Annu Rev Nutr. 2004; 24:151-72. DOI: 10.1146/annurev.nutr.24.012003.132402. View

12.

Huang L, Gitschier J . A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet. 1997; 17(3):292-7. DOI: 10.1038/ng1197-292. View

13.

da Silveira R, Hermes C, Almeida T, Bochi G, De Bona K, Moretto M . Ischemia-modified albumin and inflammatory biomarkers in patients with prostate cancer. Clin Lab. 2015; 60(10):1703-8. DOI: 10.7754/clin.lab.2014.131018. View

14.

Singh C, Chhabra G, Patel A, Chang H, Ahmad N . Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management. Nutrients. 2021; 13(6). PMC: 8226978. DOI: 10.3390/nu13061867. View

15.

Hojyo S, Fukada T . Roles of Zinc Signaling in the Immune System. J Immunol Res. 2016; 2016:6762343. PMC: 5107842. DOI: 10.1155/2016/6762343. View

16.

Herzberg M, Lusky A, Blonder J, Frenkel Y . The effect of estrogen replacement therapy on zinc in serum and urine. Obstet Gynecol. 1996; 87(6):1035-40. DOI: 10.1016/0029-7844(96)00044-0. View

17.

Leitzmann M, Stampfer M, Wu K, Colditz G, Willett W, Giovannucci E . Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2003; 95(13):1004-7. DOI: 10.1093/jnci/95.13.1004. View

18.

Clark L, Combs Jr G, Turnbull B, Slate E, Chalker D, Chow J . Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996; 276(24):1957-63. View

19.

Johnson E, Butler K, Gupta S . Bone Health in Patients With Prostate Cancer: An Evidence-Based Algorithm. Fed Pract. 2021; 38(Suppl 3):S20-S26. PMC: 8560120. DOI: 10.12788/fp.0155. View

20.

Karunasinghe N, Han D, Goudie M, Zhu S, Bishop K, Wang A . Prostate disease risk factors among a New Zealand cohort. J Nutrigenet Nutrigenomics. 2013; 5(6):339-51. DOI: 10.1159/000346279. View