Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia

Overview

Journal Urol Clin North Am

Specialty Urology

Date 2016 Aug 1

PMID 27476121

Citations 60

Authors

LaTayia Aaron

Omar E Franco

Simon W Hayward

Affiliations

Soon will be listed here.

Abstract

Prostate development follows a common pattern between species and depends on the actions of androgens to induce and support ductal branching morphogenesis of buds emerging from the urogenital sinus. The human prostate has a compact zonal anatomy immediately surrounding the urethra and below the urinary bladder. Rodents have a lobular prostate with lobes radiating away from the urethra. The human prostate is the site of benign hyperplasia, prostate cancer, and prostatitis. The rodent prostate has little naturally occurring disease. Rodents can be used to model aspects of human benign hyperplasia, but care should be taken in data interpretation and extrapolation to the human condition.

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