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Ann Katrin Sauer

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Articles 18
Citations 356
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Recent Articles
1.
Hans S, Stanton J, Sauer A, Shiels K, Saha S, Lordan R, et al.
Lipids Health Dis . 2024 Apr; 23(1):113. PMID: 38643113
Background: Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (Aβ) peptides are a well-described pathology in Alzheimer's disease (AD). Activated astrocytes surrounding Aβ plaques contribute to inflammation by...
2.
Coelho R, De Benedictis C, Sauer A, Figueira A, Faustino H, Grabrucker A, et al.
Int J Mol Sci . 2024 Feb; 25(3). PMID: 38339064
Proteinaceous aggregates accumulate in neurodegenerative diseases such as Alzheimer's Disease (AD), inducing cellular defense mechanisms and altering the redox status. S100 pro-inflammatory cytokines, particularly S100B, are activated during AD, but...
3.
Malijauskaite S, Sauer A, Hickey S, Franzoni M, Grabrucker A, McGourty K
Cell Mol Life Sci . 2022 Nov; 79(12):589. PMID: 36371739
Autism spectrum disorders (ASD) are neurodevelopmental disorders. Genetic factors, along with non-genetic triggers, have been shown to play a causative role. Despite the various causes, a triad of common symptoms...
4.
Duskey J, Rinaldi A, Ottonelli I, Caraffi R, De Benedictis C, Sauer A, et al.
Pharmaceutics . 2022 Jul; 14(7). PMID: 35890345
Glioblastoma Multiforme (GBM) is a devastating disease with a low survival rate and few efficacious treatment options. The fast growth, late diagnostics, and off-target toxicity of currently used drugs represent...
5.
Sauer A, Hagmeyer S, Grabrucker A
Int J Mol Sci . 2022 Jun; 23(11). PMID: 35682762
Epidemiological studies have shown a clear association between early life zinc deficiency and Autism Spectrum Disorders (ASD). In line with this, mouse models have revealed prenatal zinc deficiency as a...
6.
Sauer A, Malijauskaite S, Meleady P, Boeckers T, McGourty K, Grabrucker A
Cell Mol Life Sci . 2021 Dec; 79(1):46. PMID: 34936034
Gastrointestinal (GI) problems and microbiota alterations have been frequently reported in autism spectrum disorders (ASD). In addition, abnormal perinatal trace metal levels have been found in ASD. Accordingly, mice exposed...
7.
De Benedictis C, Haffke C, Hagmeyer S, Sauer A, Grabrucker A
Int J Mol Sci . 2021 Apr; 22(9). PMID: 33925953
In the last years, research has shown that zinc ions play an essential role in the physiology of brain function. Zinc acts as a potent neuromodulatory agent and signaling ions,...
8.
Sauer A, Vela H, Vela G, Stark P, Barrera-Juarez E, Grabrucker A
Front Oncol . 2020 Aug; 10:1293. PMID: 32850402
Research has been consistently showing the role of zinc (Zn) in prostate function. In this article, we review the current literature on the anatomy and main functions of the prostate,...
9.
Sauer A, Grabrucker A
Front Neurosci . 2019 Dec; 13:1295. PMID: 31849598
Zinc is an essential trace metal for bacteria of the intestinal flora. Approximately 20% of dietary zinc - intake is used by intestinal bacteria. The microbiome has recently been described...
10.
Pederzoli F, Ruozi B, Duskey J, Hagmeyer S, Sauer A, Grabrucker S, et al.
Pharmaceutics . 2019 Nov; 11(11). PMID: 31683907
The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer's disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor...