ScATAC-pro: a Comprehensive Workbench for Single-cell Chromatin Accessibility Sequencing Data

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2020 Apr 22

PMID 32312293

Citations 31

Authors

Wenbao Yu

Yasin Uzun

Qin Zhu

Changya Chen

Kai Tan

Affiliations

Soon will be listed here.

Abstract

Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-source software for comprehensive processing, analysis, and visualization of such data generated using all existing experimental protocols. Here, we present scATAC-pro for quality assessment, analysis, and visualization of single-cell chromatin accessibility sequencing data. scATAC-pro computes a range of quality control metrics for several key steps of experimental protocols, with a flexible choice of methods. It generates summary reports for both quality assessment and downstream analysis. scATAC-pro is available at https://github.com/tanlabcode/scATAC-pro.

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