Changya Chen
Overview
Explore the profile of Changya Chen including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1127
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Recent Articles
1.
Alikarami F, Xie H, Riedel S, Goodrow H, Barrett D, Mahdavi L, et al.
Blood
. 2025 Jan;
PMID: 39841459
Stemness-associated cell states are linked to chemotherapy resistance in AML. We uncovered a direct mechanistic link between expression of the stem cell transcription factor GATA2 and drug resistance. The GATA-binding...
2.
Ding Y, Sussman J, Madden K, Loftus J, Chen R, Falkenstein C, et al.
Blood
. 2025 Jan;
145(11):1195-1210.
PMID: 39774844
Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is driven by genetic alterations that induce constitutive kinase signaling and is associated with chemoresistance and high relapse risk in children and...
3.
Xu J, Chen C, Sussman J, Yoshimura S, Vincent T, Polonen P, et al.
Nat Cancer
. 2024 Nov;
6(1):102-122.
PMID: 39587259
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been implicated in treatment failure, the...
4.
Teachey D, Newman H, Lee S, Polonen P, Shraim R, Li Y, et al.
Res Sq
. 2024 Aug;
PMID: 39184069
The influence of genetic ancestry on biology, survival outcomes, and risk stratification in T-cell Acute Lymphoblastic Leukemia (T-ALL) has not been explored. Genetic ancestry was genomically-derived from DNA-based single nucleotide...
5.
Polonen P, Di Giacomo D, Seffernick A, Elsayed A, Kimura S, Benini F, et al.
Nature
. 2024 Aug;
632(8027):1082-1091.
PMID: 39143224
T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in...
6.
Chen C, Cai Y, He B, Zhang Q, Liang D, Wang Y, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000574
, commonly known as the Chinese guger tree, is highly adaptable and tolerant of poor soil conditions. It is one of the primary species forming the evergreen broad-leaved forests in...
7.
Bandyopadhyay S, Duffy M, Ahn K, Sussman J, Pang M, Smith D, et al.
Cell
. 2024 May;
187(12):3120-3140.e29.
PMID: 38714197
Non-hematopoietic cells are essential contributors to hematopoiesis. However, heterogeneity and spatial organization of these cells in human bone marrow remain largely uncharacterized. We used single-cell RNA sequencing (scRNA-seq) to profile...
8.
Bandyopadhyay S, Duffy M, Ahn K, Pang M, Smith D, Duncan G, et al.
bioRxiv
. 2024 Apr;
PMID: 38559168
The bone marrow is the organ responsible for blood production. Diverse non-hematopoietic cells contribute essentially to hematopoiesis. However, these cells and their spatial organization remain largely uncharacterized as they have...
9.
Tan K, Xu J, Chen C, Vincent T, Polonen P, Hu J, et al.
Res Sq
. 2023 Nov;
PMID: 37961674
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to cure in T-cell Acute Lymphoblastic Leukemia (T-ALL). Biomarker guided risk stratification and targeted therapy have the potential...
10.
Melenhorst J, Chen G, Wang M, Porter D, Chen C, Collins M, et al.
Nature
. 2022 Dec;
612(7941):E22.
PMID: 36477542
No abstract available.