Antimicrobial Resistance and Food Animals: Influence of Livestock Environment on the Emergence and Dissemination of Antimicrobial Resistance

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Feb 7

PMID 32023977

Citations 50

Authors

Nikola Vidovic

Sinisa Vidovic

Affiliations

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Abstract

The emergence and dissemination of antimicrobial resistance among human, animal and zoonotic pathogens pose an enormous threat to human health worldwide. The use of antibiotics in human and veterinary medicine, and especially the use of large quantities of antibiotics in livestock for the purpose of growth promotion of food animals is believed to be contributing to the modern trend of the emergence and spread of bacteria with antibiotic resistant traits. To better control the emergence and spread of antimicrobial resistance several countries from Western Europe implemented a ban for antibiotic use in livestock, specifically the use of antibiotics for growth promotion of food animals. This review article summarizes the recent knowledge of molecular acquisition of antimicrobial resistance and the effects of implementation of antibiotic growth promoter bans on the spread of antimicrobial resistant bacteria in animals and humans. In this article, we also discuss the main zoonotic transmission routes of antimicrobial resistance and novel approaches designed to prevent or slow down the emergence and spread of antimicrobial resistance worldwide. Finally, we provide future perspectives associated with the control and management of the emergence and spread of antimicrobial resistant bacteria.

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References

von Wintersdorff C, Penders J, van Niekerk J, Mills N, Majumder S, van Alphen L . Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer. Front Microbiol. 2016; 7:173. PMC: 4759269. DOI: 10.3389/fmicb.2016.00173. View

Levy S, FitzGerald G, Macone A . Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature. 1976; 260(5546):40-2. DOI: 10.1038/260040a0. View

Chiou C, Chen Y, Wang Y, Liu Y, Kuo H, Tu Y . Dissemination of -Carrying Plasmids among Colistin-Resistant Salmonella Strains from Humans and Food-Producing Animals in Taiwan. Antimicrob Agents Chemother. 2017; 61(7). PMC: 5487637. DOI: 10.1128/AAC.00338-17. View

Soni K, Nannapaneni R . Removal of Listeria monocytogenes biofilms with bacteriophage P100. J Food Prot. 2010; 73(8):1519-24. DOI: 10.4315/0362-028x-73.8.1519. View

Vidovic S, Elder J, Medihala P, Lawrence J, Predicala B, Zhang H . ZnO nanoparticles impose a panmetabolic toxic effect along with strong necrosis, inducing activation of the envelope stress response in Salmonella enterica serovar Enteritidis. Antimicrob Agents Chemother. 2015; 59(6):3317-28. PMC: 4432186. DOI: 10.1128/AAC.00363-15. View

Cano D, Pucciarelli M, Martinez-Moya M, Casadesus J, Garcia-Del Portillo F . Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Infect Immun. 2003; 71(7):3690-8. PMC: 161971. DOI: 10.1128/IAI.71.7.3690-3698.2003. View

Cotter P, Hill C, Ross R . Bacteriocins: developing innate immunity for food. Nat Rev Microbiol. 2005; 3(10):777-88. DOI: 10.1038/nrmicro1273. View

Jones N, Ray B, Ranjit K, Manna A . Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett. 2007; 279(1):71-6. DOI: 10.1111/j.1574-6968.2007.01012.x. View

Coetzee J, Corcoran C, Prentice E, Moodley M, Mendelson M, Poirel L . Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients. S Afr Med J. 2016; 106(5):35-6. DOI: 10.7196/SAMJ.2016.v106i5.10710. View

10.

Kock R, Schaumburg F, Mellmann A, Koksal M, Jurke A, Becker K . Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) as causes of human infection and colonization in Germany. PLoS One. 2013; 8(2):e55040. PMC: 3572123. DOI: 10.1371/journal.pone.0055040. View

11.

Wertheim H, Van Nguyen K, Hara G, Gelband H, Laxminarayan R, Mouton J . Global survey of polymyxin use: A call for international guidelines. J Glob Antimicrob Resist. 2014; 1(3):131-134. PMC: 3991322. DOI: 10.1016/j.jgar.2013.03.012. View

12.

Iacumin L, Manzano M, Comi G . Phage Inactivation of Listeria monocytogenes on San Daniele Dry-Cured Ham and Elimination of Biofilms from Equipment and Working Environments. Microorganisms. 2016; 4(1). PMC: 5029509. DOI: 10.3390/microorganisms4010004. View

13.

Canton R, Coque T . The CTX-M beta-lactamase pandemic. Curr Opin Microbiol. 2006; 9(5):466-75. DOI: 10.1016/j.mib.2006.08.011. View

14.

Walters R, Piddock L, Wise R . The effect of mutations in the SOS response on the kinetics of quinolone killing. J Antimicrob Chemother. 1989; 24(6):863-73. DOI: 10.1093/jac/24.6.863. View

15.

Kooti M, Sedeh A, Motamedi H, Rezatofighi S . Magnetic graphene oxide inlaid with silver nanoparticles as antibacterial and drug delivery composite. Appl Microbiol Biotechnol. 2018; 102(8):3607-3621. DOI: 10.1007/s00253-018-8880-1. View

16.

Kim N, Kang Y, Han W, Park K, Park K, Yoo J . Small-Colony Variants in Persistent and Recurrent Staphylococcus aureus Bacteremia. Microb Drug Resist. 2016; 22(7):538-544. DOI: 10.1089/mdr.2015.0262. View

17.

Kahl B, Becker K, Loffler B . Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections. Clin Microbiol Rev. 2016; 29(2):401-27. PMC: 4786882. DOI: 10.1128/CMR.00069-15. View

18.

Mather A, Reid S, Maskell D, Parkhill J, Fookes M, Harris S . Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts. Science. 2013; 341(6153):1514-7. PMC: 4012302. DOI: 10.1126/science.1240578. View

19.

Espadinha D, A Faria N, Miragaia M, Lito L, Melo-Cristino J, de Lencastre H . Extensive dissemination of methicillin-resistant Staphylococcus aureus (MRSA) between the hospital and the community in a country with a high prevalence of nosocomial MRSA. PLoS One. 2013; 8(4):e59960. PMC: 3617237. DOI: 10.1371/journal.pone.0059960. View

20.

Redgrave L, Sutton S, Webber M, Piddock L . Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success. Trends Microbiol. 2014; 22(8):438-45. DOI: 10.1016/j.tim.2014.04.007. View