Chemical Diversity in Species Belonging to Soft Coral Genus and Its Impact on Biological Activity: A Review

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2020 Jan 16

PMID 31935862

Citations 26

Authors

Yasmin A Elkhawas

Ahmed M Elissawy

Mohamed S Elnaggar

Nada M Mostafa

Eman M Kamal

Mokhtar M Bishr

Abdel Nasser B Singab

Osama M Salama

Affiliations

Soon will be listed here.

Abstract

One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus . The total number of species belonging to it was estimated to be 40. species are considered to be a reservoir of bioactive natural metabolites. Secondary metabolites isolated from members belonging to this genus show great chemical diversity. They are rich in terpenoids, in particular, cembranoids diterpenes, tetratepenoids, triterpenoids, and ceramide, in addition to steroids, sesquiterpenes, and fatty acids. They showed a broad range of potent biological activities, such as antitumor, neuroprotective, antimicrobial, antiviral, antidiabetic, antifouling, and anti-inflammatory activity. This review presents all isolated secondary metabolites from species of genera , as well as their reported biological activities covering a period of about two decades (1998-2019). It deals with 481 metabolites, including 323 diterpenes, 39 biscembranoids, 11 sesquiterpenes, 53 polyoxygenated sterols, and 55 miscellaneous and their pharmacological activities.

Citing Articles

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