Unprecedented Diterpenoids As a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton Trocheliophorum Marenzeller

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Jan 1

PMID 23273218

Citations 19

Authors

Lin-Fu Liang

Tibor Kurtan

Attila Mandi

Li-Gong Yao

Jia Li

Wen Zhang

Yue-Wei Guo

Affiliations

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Abstract

Methyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3',4']cyclobuta[1',2':4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was determined by TDDFT ECD calculations. Compound 4 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), being similar to that of positive control oleanolic acid.

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