Structurally Diverse Diterpenes from the South China Sea Soft Coral

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2023 Feb 24

PMID 36827110

Authors

Yu-Ting Song

Dan-Dan Yu

Ming-Zhi Su

Hui Luo

Jian-Guo Cao

Lin-Fu Liang

Fan Yang

Yue-Wei Guo

Affiliations

Soon will be listed here.

Abstract

The present investigation of the South China Sea soft coral resulted in the discovery of six new polyoxygenated diterpenes, namely sartrocheliols A-E (, , -) along with four known ones, , , , and . Based on extensive spectroscopic data analysis, sartrocheliol A () was identified as an uncommon capnosane diterpene, while sartrocheliols B-E (, -) were established as cembrane diterpenes. They displayed diverse structural features not only at the distinctly different carbon frameworks but also at the various types of heterocycles, including the epoxide, γ-lactone, furan, and pyran rings. Moreover, their absolute configurations were determined by a combination of quantum mechanical-nuclear magnetic resonance (QM-NMR) approach, modified Mosher's method, and X-ray diffraction analysis. In the anti-tumor bioassay, compound exhibited moderate cytotoxic activities against A549, H1975, MDA-MB-231, and H1299 cells with the IC values ranging from 26.3 to 47.9 μM.

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